Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun;30(6):1537-1538.
doi: 10.1038/s41591-024-03020-8.

Heritable and spatial immunogenic traits co-predict the efficacy of immunotherapy in kidney cancer

No authors listed

Heritable and spatial immunogenic traits co-predict the efficacy of immunotherapy in kidney cancer

No authors listed. Nat Med. 2024 Jun.
No abstract available

PubMed Disclaimer

Similar articles

Cited by

  • Trial watch: anticancer vaccination with dendritic cells.
    Borges F, Laureano RS, Vanmeerbeek I, Sprooten J, Demeulenaere O, Govaerts J, Kinget L, Saraswat S, Beuselinck B, De Vleeschouwer S, Clement P, De Smet F, Sorg RV, Datsi A, Vigneron N, Naulaerts S, Garg AD. Borges F, et al. Oncoimmunology. 2024 Oct 9;13(1):2412876. doi: 10.1080/2162402X.2024.2412876. eCollection 2024. Oncoimmunology. 2024. PMID: 39398476 Free PMC article. Review.

References

    1. Saliby, R. M. et al. Update on biomarkers in renal cell carcinoma. Am. Soc. Clin. Oncol. Educ. Book 44, e430734 (2024). This comprehensive review article highlights the current state of the art on biomarkers in RCC.
    1. Saliby, R. M. et al. Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes. Cancer Cell 42, 732–735 (2024). This recent paper reports on various molecular subtypes in RCC and demonstrates the challenges of cross-study validation of current biomarkers for immunotherapy.
    1. Naulaerts, S. et al. Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer. Sci. Transl. Med. 15, eadd1016 (2023). This paper reports on clinically relevant states of CD8+ T cells mapped via an integrative multi-omics and spatial biomarker framework. - DOI - PubMed
    1. Sprooten, J. et al. Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells. Cell Rep. Med. 5, 101377 (2024). This paper provides proof of concept for the use of reverse translation to reveal novel immunotherapy-resistance mechanisms and vaccine formulations relevant for T cell-depleted tumors. - DOI - PubMed - PMC
    1. Manczinger, M. et al. Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity. Nat. Cancer 2, 950–961 (2021). This paper reports the impact of specificity in the neo-antigen presentation of an HLA repertoire in the context of response to immunotherapy. - DOI - PubMed

LinkOut - more resources