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. 2024 May 22;11(6):ofae295.
doi: 10.1093/ofid/ofae295. eCollection 2024 Jun.

Amoxicillin and Ceftriaxone: A Synergistic Association Against Listeria monocytogenes

Thibault Sixt  1 , Florian Moretto  1 , Sylvia Das Neves  1 , Lucie Amoureux  2   3 , Catherine Neuwirth  2   3 , Lionel Piroth  1   4 , Mathieu Blot  1   4   5 , Pascal Chavanet  1   4 , Julien Bador  2
Affiliations

Amoxicillin and Ceftriaxone: A Synergistic Association Against Listeria monocytogenes

Thibault Sixt et al. Open Forum Infect Dis. .

Abstract

Among 15 strains of Listeria monocytogenes tested, a synergy between amoxicillin and ceftriaxone was observed in 14 (93%) according to minimal inhibitory concentration strips and 12 (80%) per the checkerboard methods, as well as for 2 of the 3 strains tested by the time-killing curve. This association may be an alternative treatment for listeriosis in the future.

Keywords: amoxicillin; ceftriaxone; gentamicin; listeriosis; synergy.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts.

Figures

Figure 1.
Figure 1.
Time killing curves: A, strain 3 (strong AMX + CTR synergy with microdilution); B, strain 6 (no AMX + CTR synergy with microdilution); C, strain 10 (moderate AMX + CTR synergy with microdilution). AMX, amoxicillin; CFU, colony-forming units; CTR, ceftriaxone; GM, gentamicin.
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