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Review
. 2024 May 21:15:1395479.
doi: 10.3389/fimmu.2024.1395479. eCollection 2024.

Recent advances in molecular mechanisms of skin wound healing and its treatments

Abdullah Al Mamun  1 , Chuxiao Shao  1 , Peiwu Geng  1 , Shuanghu Wang  1 , Jian Xiao  1   2   3
Affiliations
Review

Recent advances in molecular mechanisms of skin wound healing and its treatments

Abdullah Al Mamun et al. Front Immunol. .

Abstract

The skin, being a multifaceted organ, performs a pivotal function in the complicated wound-healing procedure, which encompasses the triggering of several cellular entities and signaling cascades. Aberrations in the typical healing process of wounds may result in atypical scar development and the establishment of a persistent condition, rendering patients more vulnerable to infections. Chronic burns and wounds have a detrimental effect on the overall quality of life of patients, resulting in higher levels of physical discomfort and socio-economic complexities. The occurrence and frequency of prolonged wounds are on the rise as a result of aging people, hence contributing to escalated expenditures within the healthcare system. The clinical evaluation and treatment of chronic wounds continue to pose challenges despite the advancement of different therapeutic approaches. This is mainly owing to the prolonged treatment duration and intricate processes involved in wound healing. Many conventional methods, such as the administration of growth factors, the use of wound dressings, and the application of skin grafts, are used to ease the process of wound healing across diverse wound types. Nevertheless, these therapeutic approaches may only be practical for some wounds, highlighting the need to advance alternative treatment modalities. Novel wound care technologies, such as nanotherapeutics, stem cell treatment, and 3D bioprinting, aim to improve therapeutic efficacy, prioritize skin regeneration, and minimize adverse effects. This review provides an updated overview of recent advancements in chronic wound healing and therapeutic management using innovative approaches.

Keywords: immune cell-wound healing; skin; skin wound healing; stem cell therapy; wound physical therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of Wound healing.
Figure 2
Figure 2
Role of macrophage, mast cell, and neutrophil in wound healing.
Figure 3
Figure 3
Apoptosis and autophagy in wound healing.
Figure 4
Figure 4
Ferroptosis in wound healing.
Figure 5
Figure 5
Apoptosis and ferroptosis in wound healing.
Figure 6
Figure 6
Role of pyroptosis in inflammation during skin wound healing.
Figure 7
Figure 7
Role of fibroblast and myofibroblast in the proliferative phase.
See this image and copyright information in PMC

References

    1. Díaz-García D, Filipová A, Garza-Veloz I, Martinez-Fierro ML. A beginner’s introduction to skin stem cells and wound healing. Int J Mol Sci. (2021) 22:11030. doi: 10.3390/ijms222011030 - DOI - PMC - PubMed
    1. Aragona M, Dekoninck S, Rulands S, Lenglez S, Mascré G, Simons BD, et al. . Defining stem cell dynamics and migration during wound healing in mouse skin epidermis. Nat Commun. (2017) 8:14684. doi: 10.1038/ncomms14684 - DOI - PMC - PubMed
    1. Chou WC, Takeo M, Rabbani P, Hu H, Lee W, Chung YR, et al. . Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling. Nat Med. (2013) 19:924–9. doi: 10.1038/nm.3194 - DOI - PMC - PubMed
    1. Leclère FM. The use of integra® Dermal regeneration template versus flaps for reconstruction of full-thickness scalp defects involving the calvaria: A cost–benefit analysis. Aesthetic Plast Surg. (2017) 41:472–3. doi: 10.1007/s00266-016-0765-z - DOI - PubMed
    1. Boyce ST, Lalley AL. Tissue engineering of skin and regenerative medicine for wound care. Burn Trauma. (2018) 6:4. doi: 10.1186/s41038-017-0103-y - DOI - PMC - PubMed

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