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Editorial
. 2024 Jun 3;8(6):e83.
doi: 10.1002/hem3.83. eCollection 2024 Jun.

How to put a hex on HOX

Robert K Slany  1
Affiliations
Editorial

How to put a hex on HOX

Robert K Slany. Hemasphere. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
HOXA9 function and principles of HOXA9 targeting. HOXA9 is a pioneering transcription factor that can prepare chromatin for the establishment of developmental enhancers. On a subset of initial binding sites, higher‐order complexes of HOXA9 with MEIS1 and PBX3 as well as other hematopoietic transcription factors assemble and demarcate high‐activity enhancers (enhancer sharpening) necessary for self‐renewal and proliferation of precursor cells. Strategies to interfere with this process include the prevention of HOX/cofactor expression by menin inhibitors, peptides that block multimer formation (HXR9), and, as a new strategy, small molecules that interfere with HOXA9 binding to DNA (DB818/1055).
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References

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