Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Jun 3;8(6):e83.
doi: 10.1002/hem3.83. eCollection 2024 Jun.

How to put a hex on HOX

Robert K Slany  1
Affiliations
Editorial

How to put a hex on HOX

Robert K Slany. Hemasphere. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
HOXA9 function and principles of HOXA9 targeting. HOXA9 is a pioneering transcription factor that can prepare chromatin for the establishment of developmental enhancers. On a subset of initial binding sites, higher‐order complexes of HOXA9 with MEIS1 and PBX3 as well as other hematopoietic transcription factors assemble and demarcate high‐activity enhancers (enhancer sharpening) necessary for self‐renewal and proliferation of precursor cells. Strategies to interfere with this process include the prevention of HOX/cofactor expression by menin inhibitors, peptides that block multimer formation (HXR9), and, as a new strategy, small molecules that interfere with HOXA9 binding to DNA (DB818/1055).
See this image and copyright information in PMC

Comment on

References

    1. Khan I, Amin MA, Eklund EA, Gartel AL. Regulation of HOX gene expression in AML. Blood Cancer J. 2024;14(1):42. 10.1038/s41408-024-01004-y - DOI - PMC - PubMed
    1. Sun Y, Zhou B, Mao F, et al. HOXA9 reprograms the enhancer landscape to promote leukemogenesis. Cancer Cell. 2018;34(4):643‐658.e5. 10.1016/j.ccell.2018.08.018 - DOI - PMC - PubMed
    1. Garcia‐Cuellar MP, Prinz A, Slany RK. Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc. Haematologica. 2022;107(11):2601‐2616. 10.3324/haematol.2022.280831 - DOI - PMC - PubMed
    1. Miyamoto R, Kanai A, Okuda H, et al. HOXA9 promotes MYC‐mediated leukemogenesis by maintaining gene expression for multiple anti‐apoptotic pathways. eLife. 2021;10:e64148. 10.7554/eLife.64148 - DOI - PMC - PubMed
    1. Zhong X, Prinz A, Steger J, et al. HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes. Blood Adv. 2018;2(22):3137‐3148. 10.1182/bloodadvances.2018025866 - DOI - PMC - PubMed