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Meta-Analysis
. 2024 Jan-Dec:23:15330338241246457.
doi: 10.1177/15330338241246457.

The Relationship Between the hOGG1 rs1052133 Polymorphism and the Occurrence of Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis

Guanglie Li  1 , Jijin Yao  1 , Fan Zhang  1 , Xiwei Xu  1 , Siyang Wang  1
Affiliations
Meta-Analysis

The Relationship Between the hOGG1 rs1052133 Polymorphism and the Occurrence of Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis

Guanglie Li et al. Technol Cancer Res Treat. 2024 Jan-Dec.

Abstract

Objectives: Exploring the relationship between the hOGG1 rs1052133 polymorphism and the occurrence of nasopharyngeal carcinoma (NPC). Methods: PubMed, Web of Science, Scopus, CNKI, Wanfangdata, and VIP were used to search for studies and the NOS evaluation scale was used to evaluate the quality. All studies were grouped according to different genotypes. The Cochrane's Q test and I2 test were used for heterogeneity evaluations. If heterogeneity was small, the fixed effects model was used, and conversely, the random effects model was used. Publication bias was also detected. P < .05 in all results indicated statistically significant. Results: We ultimately included 6 studies with 2021 NPC patients in the study group and 2375 healthy populations in the control group. After meta-analysis, it was found that the total OR value of the "Ser/Cys (CG) vs Ser/Ser (CC)" group was 1.00 (95% CI: 0.85-1.18) and the "Cys/Cys (GG) vs Ser/Ser (CC)" group was 1.06 (95% CI: 0.87-1.28). These results were not statistically significant (P > .05). Furthermore, the integrated total OR values of each group were not statistically significant with or without the smoking history, even in other genotype models (Allele, Dominant, Recessive, and Additive) (P > .05). Conclusion: There is no clear correlation between the hOGG1 rs1052133 polymorphism and the occurrence of NPC, even with or without the smoking history.

Keywords: hOGG1; meta; nasopharyngeal carcinoma; polymorphism; rs1052133.

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Conflict of interest statement

Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The flow chart of the study selection.
Figure 2.
Figure 2.
TSA for hOGG1 rs1052133 polymorphism.
Figure 3.
Figure 3.
Forest plot of the relationship between the different genotype groups of hOGG1 rs1052133 and the occurrence of NPC.
Figure 4.
Figure 4.
Funnel plots of the relationship between the different genotype groups of hOGG1 rs1052133 and the occurrence of NPC. (A) The funnel plot of the “CG vs CC” subgroup. (B) The funnel plot of the “GG vs CC” subgroup.
Figure 5.
Figure 5.
The forest plot of the relationship between the different genotypes of hOGG1 rs1052133 and the occurrence of NPC under different smoking conditions. (A) The forest plot of the relationship between the different genotypes of hOGG1 rs1052133 and the occurrence of NPC with the smoking history. (B) The forest plot of the relationship between the different genotypes of hOGG1 rs1052133 and the occurrence of NPC without the smoking history.
Figure 6.
Figure 6.
Forest plot of the relationship between the different genotype groups of hOGG1 rs1052133 and the occurrence of NPC in other genotype models.
Figure 7.
Figure 7.
The effects of different genotypes of rs1052133 (CG or GG) on the expression of hOGG1 mRNA in human tissues. (A) In muscle-skeletal. (B) In cultured fibroblasts cells. (C) In sun-exposed skin (lower leg).
Figure 8.
Figure 8.
(A) The expression of hOGG1 in normal tissues and head and neck squamous cell carcinoma tissues. (B) The effect of hOGG1 on OS in patients with head and neck squamous cell carcinoma. (C) The effect of hOGG1 on DFS in patients with head and neck squamous cell carcinoma.
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