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. 1985 Jan;7(1):70-2.
doi: 10.1080/01652176.1985.9693956.

In vitro antimicrobial activity of hydroxy and N4-acetyl sulphonamide metabolites

J F Nouws, T B Vree, Y A Hekster
Free article

In vitro antimicrobial activity of hydroxy and N4-acetyl sulphonamide metabolites

J F Nouws et al. Vet Q. 1985 Jan.
Free article

Abstract

Hydroxylated metabolites of sulphadimidine, sulphamerazine, sulphatroxazole, sulphamethoxazole, and sulphadiazine exhibited antimicrobial activity against Escherichia coli 28 PR 271 test strain ranging from 2.5 to 39.5 per cent of that of the parent drug. Trimethoprim addition potentiated the antimicrobial activity of these metabolites. N4-acetyl sulphonamide metabolites possessed no antimicrobial activity, nor did trimethoprim potentiated them.

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