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. 2024 Oct;193(5):2293-2299.
doi: 10.1007/s11845-024-03720-7. Epub 2024 Jun 5.

Relationship of lncRNA FTX and miR-186-5p levels with diabetic peripheral neuropathy in type 2 diabetes and its bioinformatics analysis

Baoqiang Guo #  1 , Xiuli Xu #  2 , Xuexiu Chi  3 , Min Wang  4
Affiliations

Relationship of lncRNA FTX and miR-186-5p levels with diabetic peripheral neuropathy in type 2 diabetes and its bioinformatics analysis

Baoqiang Guo et al. Ir J Med Sci. 2024 Oct.

Abstract

Background: Diabetic peripheral neuropathy (DPN) frequently occurs as a secondary condition in individuals with type 2 diabetes mellitus (T2DM).

Objective: To explore the relationship of lncRNA FTX and miR-186-5p levels with DPN in T2DM.

Methods: The study enrolled 50 patients with T2DM and 45 patients with DPN. Expression levels of FTX and miR-186-5p were measured by RT-qPCR. The levels of MDA, GSH, and SOD in the serum were measured to assess the patients' oxidative stress levels. In addition, the target genes of miR-186-5p were analyzed by bioinformatics.

Results: Serum FTX levels were increased and miR-186-5p levels were decreased in patients with T2DM and DPN. Both of them had high diagnostic value for T2DM and DPN. In addition, FTX and miR-186-5p were risk factors for the onset of DPN in people with T2DM and were significantly correlated with oxidative stress indicators in patients.

Conclusion: FTX and miR-186-5p are closely related to the disease progression of DPN in people with T2DM and may become therapeutic targets for DPN in people with T2DM.

Keywords: Diabetic peripheral neuropathy; FTX; Type 2 diabetes mellitus; miR-186-5p.

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