Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;46(6):6141-6156.
doi: 10.1007/s11357-024-01193-1. Epub 2024 Jun 5.

Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: results from the InCHIANTI study

Maria Luisa Brandi  1 , Francesca Marini  2 , Simone Parri  2 , Stefania Bandinelli  3 , Teresa Iantomasi  4 , Francesca Giusti  4   5 , Eleonora Talluri  4 , Giovanna Sini  4 , Fabrizio Nannipieri  6 , Santina Battaglia  6 , Giovanni Tripepi  7 , Colin Gerard Egan  8 , Luigi Ferrucci  9
Affiliations

Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: results from the InCHIANTI study

Maria Luisa Brandi et al. Geroscience. 2024 Dec.

Abstract

Few studies have evaluated the association between circulating levels of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and the endocrine disruptor bisphenol A (BPA), with risk of cardiovascular (CV) disease in elderly individuals. This was a cross-sectional study in a subgroup of elderly people from the InCHIANTI Biobank in Italy. We examined the association between circulating serum vitamin D metabolites, 1,25(OH)2D, 25(OH)D, and the endocrine disrupting agent BPA, with an arbitrary CV risk score and the European Society of Cardiology-based 10-year CV risk (SCORE2/SCORE2-OP) using univariate and multiple regression. In 299 individuals, blood samples were tested for serum values of 25(OH)D, 1,25(OH)2D and urinary BPA levels. One hundred eighty individuals (60.2%) were deficient (< 20 ng/ml) in 25(OH)D. Levels of 25(OH)D and 1,25(OH)2D were negatively correlated with CV risk score (p < 0.0001 for both) as well as SCORE2/SCORE2-OP (p < 0.0001 for both) while BPA levels were positively correlated with both CV risk scores (p < 0.0001 for both). In a logistic regression model, male gender (odds ratio; OR: 2.1, 95% CI:1.1-3.8, p = 0.022), obesity (OR:2.8, 95% CI:1.2-6.5, p = 0.016) and BPA levels ≥ 110 ng/dl (OR:20.9, 95% CI:9.4-46.8, p < 0.0001) were associated with deficient levels of 25(OH)D. 1,25(OH)2D levels < 41 ng/dl and 25(OH)D levels < 20 ng/ml were associated with CV risk score ≥ 3 (OR: 4.16, 95% CI: 2.32-7.4, p < 0.0001 and OR: 1.86, 95% CI: 1.02-3.39, p = 0.044) respectively and 1,25(OH)2D levels < 41 ng/dl were associated with SCORE2/SCORE2-OP of ≥ 20% (OR:2.98, 95% CI: 1.7-5.2, p = 0.0001). In this cross-sectional analysis, BPA exposure was associated with significantly reduced levels of vitamin D that in turn were significantly associated with increased CV risk.

Keywords: 1,25(OH)2D; 25(OH)D; Bisphenol A; Cardiovascular risk; Elderly people; Vitamin D.

PubMed Disclaimer

Conflict of interest statement

MLB has received honoraria/grants or speaker fees from Abiogen Pharma, Alexion, Amgen, Bruno Farmaceutici, Eli Lilly, Kyowa Kirin, MSD, NPS, Servier or Shire. All other authors declare no conflict of interest. F.N., RG, S.B. are employees of Abiogen Pharma Spa, Pisa, Italy.

Figures

Fig. 1
Fig. 1
Correlation between CV risk score and serum vitamin D and BPA levels in 299 elderly individuals from the inChianti database. BPA = bisphenol A, CV = cardiovascular, r = regression coefficient
Fig. 2
Fig. 2
Correlation between SCORE2/SCORE2-OP and serum vitamin D and BPA levels in 299 elderly individuals from the inChianti database. BPA = bisphenol A, CV = cardiovascular, r = regression coefficient
Fig. 3
Fig. 3
Comparison between levels of serum vitamin D and BPA in 299 elderly individuals from the inChianti database with very high CV risk reflected by a CV risk score ≥ 3 or SCORE2/SCORE2-OP ≥ 20%. BPA = bisphenol A, CV = cardiovascular, r = regression coefficient
Fig. 4
Fig. 4
ROC analysis to assess the ability of vitamin D and BPA levels to discriminate between individuals at very high CV risk reflected by a CV risk score ≥ 3 or SCORE2/SCORE2-OP ≥ 20%. AUC = area under the curve, BPA = bisphenol A, CI = confidence interval, CV = cardiovascular
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bouillon R, Marcocci C, Carmeliet G, et al. Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev. 2019;40:1109–51. 10.1210/er.2018-00126. - PMC - PubMed
    1. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30. 10.1210/jc.2011-0385. - PubMed
    1. Minisola S, Colangelo L, Pepe J, et al. Osteomalacia and vitamin D status: a clinical update 2020. JBMR Plus. 2021;5: e10447. 10.1002/jbm4.10447. - PMC - PubMed
    1. Giannini S, Giusti A, Minisola S, et al. The immunologic profile of vitamin D and its role in different immune-mediated diseases: an expert opinion. Nutrients. 2022;14:473. 10.3390/nu14030473. - PMC - PubMed
    1. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 Pt A:138–45. 10.1016/j.jsbmb.2013.11.003. - PMC - PubMed

LinkOut - more resources