Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2024 Jul;40(5):e3827.
doi: 10.1002/dmrr.3827.

The circadian syndrome is a predictor for cognition impairment in middle-aged adults: Comparison with the metabolic syndrome

Zumin Shi  1 , Naftali Stern  2   3 , Jianghong Liu  4 , Jaakko Tuomilehto  5   6   7 , Noga Kronfeld-Schor  8 , Assam El-Osta  9   10 , George Alberti  11 , Zhonglin Chai  9 , Carmel Bilu  8 , Haim Einat  12 , Yonit Marcus  2   3 , Paul Zimmet  2   9
Affiliations
Comparative Study

The circadian syndrome is a predictor for cognition impairment in middle-aged adults: Comparison with the metabolic syndrome

Zumin Shi et al. Diabetes Metab Res Rev. 2024 Jul.

Abstract

Aims: Circadian syndrome (CircS) is considered a better predictor for cardiovascular disease than the metabolic syndrome (MetS). We aim to examine the associations between CircS and MetS with cognition in Chinese adults.

Method: We used the data of 8546 Chinese adults aged ≥40 years from the 2011 China Health and Retirement Longitudinal Study. MetS was defined using harmonised criteria. CircS included the components of MetS plus short sleep and depression. The cut-off for CircS was set as ≥4. Global cognitive function was assessed during the face-to-face interview.

Results: CircS and MetS had opposite associations with the global cognition score and self-reported poor memory. Compared with individuals without the CircS and MetS, the regression coefficients (95%CI) for global cognition score were -1.02 (-1.71 to -0.34) for CircS alone and 0.52 (0.09 to 0.96) for MetS alone in men; -1.36 (-2.00 to -0.72) for CircS alone and 0.60 (0.15 to 1.06) for MetS alone in women. Having CircS alone was 2.53 times more likely to report poor memory in men (95%CI 1.80-3.55) and 2.08 times more likely in women (95%CI 1.54-2.81). In contrast, having MetS alone was less likely to report poor memory (OR 0.64 (0.49-0.84) in men and 0.65 (0.52-0.81) in women). People with CircS and MetS combined were more likely to have self-reported poor memory.

Conclusions: CircS is a strong and better predictor for cognition impairment than MetS in Chinese middle-aged adults. MetS without short sleep and depression is associated with better cognition.

Keywords: Chinese; adults; circadian syndrome; cognition; memory; metabolic syndrome; sleep.

PubMed Disclaimer

References

REFERENCES

    1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63‐75e62. https://doi.org/10.1016/j.jalz.2012.11.007
    1. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413‐446. https://doi.org/10.1016/s0140‐6736(20)30367‐6
    1. Deng Y, Zhao S, Cheng G, et al. The prevalence of mild cognitive impairment among Chinese people: a meta‐analysis. Neuroepidemiology. 2021;55(2):79‐91. https://doi.org/10.1159/000512597
    1. Qi S, Yin P, Zhang H, et al. Prevalence of dementia in China in 2015: a nationwide community‐based study. Front Public Health. 2021;9:733314. https://doi.org/10.3389/fpubh.2021.733314
    1. Singh‐Manoux A, Kivimaki M, Glymour MM, et al. Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. BMJ. 2012;344(jan04 4):d7622. https://doi.org/10.1136/bmj.d7622

Publication types

LinkOut - more resources