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. 2024 Sep;101(3):216-222.
doi: 10.1111/cen.15094. Epub 2024 Jun 4.

The relationship between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus

Edibe S Eker  1 , Hayriye E Ataoğlu  1
Affiliations

The relationship between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus

Edibe S Eker et al. Clin Endocrinol (Oxf). 2024 Sep.

Abstract

Objective: Diabetic nephropathy is a prevalent cause of chronic kidney disease worldwide. Magnesium plays a critical role in insulin resistance, and insulin, in turn, regulates magnesium levels. We aimed to investigate the association between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus (T2DM).

Design, patients and measurements: This retrospective single-centre study encompassed 1178 patients aged 18 and above with T2DM, who attended our outpatient clinic between January 2019 and August 2020. Albuminuria levels were categorised according to Kidney Disease Outcomes Quality Initiative guidelines. In the literature, when examining cut-off values for hypomagnesemia, it is observed that studies typically use hospital normal level as a reference point. Hypomagnesemia, defined as magnesium levels below 1.6 mg/dL, was compared to normomagnesemia (magnesium between 1.6 and 2.4 mg/dL). The primary objective was to explore the impact of magnesium levels on albuminuria, while the secondary objective was to determine the prevalence of hypomagnesemia. The multivariate logistic regression analyses were performed according to age, gender (male), HbA1c, and presence of hypomagnesemia.

Results: The mean age of the participants was 58.7 ± 12.2 years, with 44% being male. Hypomagnesemia was identified in 5.3% of the patients. Advanced age and female gender were more common among patients with hypomagnesemia (p = .001). Magnesium levels exhibited a negative correlation with HbA1c and fasting blood glucose, and a positive correlation with creatinine levels (r = -.117, r = -.131, r = .117, p < .001 for all three variables). Hypomagnesemia was significantly more prevalent in patients with albuminuria (15.9% vs. 4.7%, p < .001). Moreover, participants with the presence of hypomagnesemia were independently associated with a higher risk of albuminuria (odds ratio 3,64 1.76-7.52, p = .001).

Conclusion: Albuminuria is more frequently observed in patients with hypomagnesemia.

Keywords: albuminuria; hypomagnesemia; magnesium; nephropathy; type 2 diabetes mellitus.

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References

REFERENCES

    1. Litwak L, Goh SY, Hussein Z, Malek R, Prusty V, Khamseh ME. Prevalence of diabetes complications in people with type 2 diabetes mellitus and its association with baseline characteristics in the multinational A1chieve study. Diabetol Metab Syndr. 2013;5(1):57.
    1. Gregg EW, Sattar N, Ali MK. The changing face of diabetes complications. Lancet Diabetes Endocrinol. 2016;4:537‐547.
    1. Maggiore U, Budde K, Heemann U, et al. Long‐term risks of kidney living donation: review and position paper by the ERA‐EDTA DESCARTES working group. Nephrol Dial Transplant. 2017;32:216‐223.
    1. Long AN, Dagogo‐Jack S. Comorbidities of diabetes and hypertension: mechanisms and approach to target organ protection. J Clin Hypertens. 2011;13:244‐251.
    1. Lu J, Gu Y, Guo M, Chen P, Wang H, Yu X. Serum magnesium concentration is inversely associated with albuminuria and retinopathy among patients with diabetes. J Diabetes Res. 2016;2016:1‐6.

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