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. 2024 Nov 1;63(11):2911-2913.
doi: 10.1093/rheumatology/keae319.

New insights into which ACPA-positive individuals will develop clinical rheumatoid arthritis

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New insights into which ACPA-positive individuals will develop clinical rheumatoid arthritis

Kevin D Deane. Rheumatology (Oxford). .
No abstract available

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Figures

Figure 1.
Figure 1.
Natural history of RA. In this model, individuals who are in a stage of preclinical RA (also known as an ‘at-risk’ period) can be identified through symptoms, biomarker abnormalities, and imaging findings, but they do not have a swollen joint on physical examination. Clinical RA is defined by the presence of a swollen joint that may or may not additionally meet established classification criteria for RA. Notably, a combination of symptoms, biomarker abnormalities, and imaging findings found in individuals who have presented to rheumatology clinics may represent a late-stage of preclinical RA. MSK: musculoskeletal

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References

    1. Krijbolder DI, Verstappen M, van Dijk BT et al. Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet 2022;400:283–94. - PubMed
    1. Cope AP, Jasenecova M, Vasconcelos JC et al.; APIPPRA Study Investigators. Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial. Lancet 2024;403:838–49. - PubMed
    1. Rech J, Tascilar K, Hagen M et al. Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial. Lancet 2024;403:850–9. - PubMed
    1. Duquenne L, Hensor EM, Wilson M et al. Predicting inflammatory arthritis in at-risk persons: development of scores for risk stratification. Ann Intern Med 2023;176:1027–36. - PubMed
    1. Perera PY, Lichy JH, Waldmann TA, Perera LP. The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes Infect 2012;14:247–61. - PMC - PubMed