doi: 10.1016/j.cmet.2024.05.007.
Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer
Affiliations
- PMID: 38838639
- DOI: 10.1016/j.cmet.2024.05.007
Item in Clipboard
Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer
Cell Metab.
.
Free article
Abstract
Some cancers prefer to metabolize lipids for their growth and metastasis. In a recent Cancer Cell study, Niu et al. revealed that SET domain containing 2, histone lysine methyltransferase (SETD2)-deficient pancreatic cancer cells induce the differentiation of lipid-laden cancer-associated fibroblasts (CAFs), which, in turn, transport lipids to promote tumor growth.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Similar articles
-
Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts.Cancer Cell. 2024 May 13;42(5):744-746. doi: 10.1016/j.ccell.2024.04.001. Epub 2024 Apr 25. Cancer Cell. 2024. PMID: 38670089 Free PMC article.
-
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.Cancer Cell. 2024 May 13;42(5):869-884.e9. doi: 10.1016/j.ccell.2024.03.005. Epub 2024 Apr 4. Cancer Cell. 2024. PMID: 38579725
-
Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma.Cancer Med. 2017 Feb;6(2):463-470. doi: 10.1002/cam4.993. Epub 2017 Jan 18. Cancer Med. 2017. PMID: 28097809 Free PMC article.
-
Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment.Front Immunol. 2023 Mar 22;14:1152312. doi: 10.3389/fimmu.2023.1152312. eCollection 2023. Front Immunol. 2023. PMID: 37033960 Free PMC article. Review.
-
Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment.Front Endocrinol (Lausanne). 2022 Aug 15;13:988295. doi: 10.3389/fendo.2022.988295. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36046791 Free PMC article. Review.
Cited by
-
Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis.J Nanobiotechnology. 2025 Jul 26;23(1):540. doi: 10.1186/s12951-025-03612-7. J Nanobiotechnology. 2025. PMID: 40713812 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
