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. 2024 Jun 4;36(6):1172-1174.
doi: 10.1016/j.cmet.2024.05.007.

Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer

Kostas A Papavassiliou  1 , Athanasios G Papavassiliou  2
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Free article

Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer

Kostas A Papavassiliou et al. Cell Metab. .
Free article

Abstract

Some cancers prefer to metabolize lipids for their growth and metastasis. In a recent Cancer Cell study, Niu et al. revealed that SET domain containing 2, histone lysine methyltransferase (SETD2)-deficient pancreatic cancer cells induce the differentiation of lipid-laden cancer-associated fibroblasts (CAFs), which, in turn, transport lipids to promote tumor growth.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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