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. 2024 Aug;271(8):5650-5655.
doi: 10.1007/s00415-024-12478-y. Epub 2024 Jun 5.

Myasthenic crises are associated with negative long-term outcomes in myasthenia gravis

Anna Mück  1 , Steffen Pfeuffer  2 , Lara Mir  2 , Sonja Genau  2 , Julia Emde  2 , Linus Olbricht  2 , Omar A Omar  2 , Franz Blaes  3 , Christoph Best  4 , Hagen B Huttner  2 , Heidrun H Krämer  2
Affiliations

Myasthenic crises are associated with negative long-term outcomes in myasthenia gravis

Anna Mück et al. J Neurol. 2024 Aug.
No abstract available

Keywords: Disease outcomes; Myasthenia gravis; Myasthenic exacerbation; Real-world study.

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Conflict of interest statement

A.M: no conflicts of interest. S.P.: received travel grants from Sanofi, Roche Pharma and Merck Healthcare, lecturing honoraria and consulting fees from Sanofi, Mylan, Novartis, Merck Healthcare, Biogen, Hexal, Alexion, Roche Pharma, and research support from Diamed, Merck, Biogen, Novartis and the German Multiple Sclerosis Society North-Rhine-Westphalia. L.M.: no conflicts of interest. S.G.: no conflicts of interest. J.E.: no conflicts of interest. L.O.: no conflicts of interest. O.A.O: no conflicts of interest. C.B.: received lecturing honoraria and consulting fees from Novartis, Bayer and Portola. F.B. received travel grants from alexion, lecturing honoraria and consulting fees from UCB, argenX and Grifols. H.B.H.: received personal honoraria and/or unrestricted research grants from Portola Pharmaceuticals, Boehringer Ingelheim, Daiichi Sanyko, Bayer AG, Novartis, Astrazeneca and CSL Behring outside the submitted work. H.H.K.: received travel grants Alexion and Grifols, lecturing honoraria and consulting fees from Sanofi, Alexion, Roche Pharma, Argenx, UCB and research support from Roche.

Figures

Fig. 1
Fig. 1
depicts the course of QMG during the observation period in ME+ (black squares) and ME− (open squares) patients. Repeated measures ANOVA showed that the time course of QMG is significantly different between the two groups of patients (F = 8.2; p = 0.006). Further analysis revealed that QMG scores are significantly higher in ME+ patients at the first visit in the outpatient clinic after ME (F = 19, p < 0.001) as well as after three (F = 21.0, p < 0.001) and six months (F = 6.5, p = 0.013). At 9 months, there is a tendency for higher QMG scores in the ME+ group, however, level of significance is not met (F = 2.6, p = 0.072). At 12 months, no significant difference could be found (F = 2.3; p = 0.13). **p < 0.01
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