Comparative Study

. 2024 Oct;54(10):1173-1183.

doi: 10.1007/s00595-024-02827-9. Epub 2024 Jun 5.

Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan

Collaborators, Affiliations

Collaborators

Japan Society of Laparoscopic Colorectal Surgery:
Eiji Kanehira, Kunihisa Shiozawa, Hiroyuki Bando, Daisuke Yamamoto, Seigo Kitano, Masafumi Inomata, Tomonori Akagi, Junji Okuda, Keitaro Tanaka, Masayoshi Yasui, Kosei Hirakawa, Kiyoshi Maeda, Akiyoshi Kanazawa, Junichi Hasegawa, Junichi Nishimura, Shintaro Akamoto, Masashi Ueno, Hiroya Kuroyanagi, Masaki Naito, Takashi Ueki, Yoshiharu Sakai, Koya Hida, Yousuke Kinjo, Yukihito Kokuba, Madoka Hamada, Norio Saito, Masaaki Ito, Shigeki Yamaguchi, Jou Tashiro, Toshimasa Yatsuoka, Tomohisa Furuhata, Kenji Okita, Yoshiro Kubo, Shuji Saito, Yosuke Kinugasa, Fumio Konishi, Kazuhiro Sakamoto, Michitoshi Goto, Junichi Tanaka, Nobuyoshi Miyajima, Tadashi Suda, Tsukasa Shimamura, Yoshihisa Saida, Toshiyuki Enomoto, Takeshi Naito, Yasuhiro Munakata, Ken Hayashi, Yasukimi Takii, Satoshi Maruyama, Yohei Kurose, Yasuhiro Miyake, Shoichi Hazama, Shoich Fujii, Shigeru Yamagishi, Masazumi Okajima, Seiichiro Yamamoto, Hisanaga Horie, Kohei Murata, Kenichi Sugihara

Affiliations

¹ Department of Surgery, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure, Hiroshima, 737-0023, Japan.
² Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
³ Department of Clinical and Molecular Genetics, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
⁴ Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
⁵ Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi, 464-8681, Japan.
⁶ Department of Gastroenterological Surgery, Tokai University School of Medicine, 43 Shimokasuya, Isehara, Kanagawa, 259-1103, Japan.
⁷ Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizu-Wakamatsu City, Fukushima, 969-3492, Japan.
⁸ Department of Surgery, Kyoto University Hospital, Kyoto, Japan.
⁹ Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
¹⁰ Department of Surgery, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-Ku, Tokyo, Japan.
¹¹ Department of Gastrointestinal Surgery, Niigata Cancer Center Hospital, 2-15-3 Kawagishicho, Niigata, 951-8566, Japan.
¹² Department of Surgery, Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-Ku, Tokyo, 179-0072, Japan.
¹³ Department of Surgery, Kitasato University Kitasato Institute Hospital, Shirokane 5-9-1, Minato-Ku, Tokyo, 108-8642, Japan.

PMID: 38839654
PMCID: PMC11413077
DOI: 10.1007/s00595-024-02827-9

Comparative Study

Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan

Haruki Sada et al. Surg Today. 2024 Oct.

. 2024 Oct;54(10):1173-1183.

doi: 10.1007/s00595-024-02827-9. Epub 2024 Jun 5.

Authors

Collaborators

Japan Society of Laparoscopic Colorectal Surgery:
Eiji Kanehira, Kunihisa Shiozawa, Hiroyuki Bando, Daisuke Yamamoto, Seigo Kitano, Masafumi Inomata, Tomonori Akagi, Junji Okuda, Keitaro Tanaka, Masayoshi Yasui, Kosei Hirakawa, Kiyoshi Maeda, Akiyoshi Kanazawa, Junichi Hasegawa, Junichi Nishimura, Shintaro Akamoto, Masashi Ueno, Hiroya Kuroyanagi, Masaki Naito, Takashi Ueki, Yoshiharu Sakai, Koya Hida, Yousuke Kinjo, Yukihito Kokuba, Madoka Hamada, Norio Saito, Masaaki Ito, Shigeki Yamaguchi, Jou Tashiro, Toshimasa Yatsuoka, Tomohisa Furuhata, Kenji Okita, Yoshiro Kubo, Shuji Saito, Yosuke Kinugasa, Fumio Konishi, Kazuhiro Sakamoto, Michitoshi Goto, Junichi Tanaka, Nobuyoshi Miyajima, Tadashi Suda, Tsukasa Shimamura, Yoshihisa Saida, Toshiyuki Enomoto, Takeshi Naito, Yasuhiro Munakata, Ken Hayashi, Yasukimi Takii, Satoshi Maruyama, Yohei Kurose, Yasuhiro Miyake, Shoichi Hazama, Shoich Fujii, Shigeru Yamagishi, Masazumi Okajima, Seiichiro Yamamoto, Hisanaga Horie, Kohei Murata, Kenichi Sugihara

Affiliations

¹ Department of Surgery, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure, Hiroshima, 737-0023, Japan.
² Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
³ Department of Clinical and Molecular Genetics, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
⁴ Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. thinoi@hiroshima-u.ac.jp.
⁵ Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi, 464-8681, Japan.
⁶ Department of Gastroenterological Surgery, Tokai University School of Medicine, 43 Shimokasuya, Isehara, Kanagawa, 259-1103, Japan.
⁷ Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizu-Wakamatsu City, Fukushima, 969-3492, Japan.
⁸ Department of Surgery, Kyoto University Hospital, Kyoto, Japan.
⁹ Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
¹⁰ Department of Surgery, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-Ku, Tokyo, Japan.
¹¹ Department of Gastrointestinal Surgery, Niigata Cancer Center Hospital, 2-15-3 Kawagishicho, Niigata, 951-8566, Japan.
¹² Department of Surgery, Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-Ku, Tokyo, 179-0072, Japan.
¹³ Department of Surgery, Kitasato University Kitasato Institute Hospital, Shirokane 5-9-1, Minato-Ku, Tokyo, 108-8642, Japan.

PMID: 38839654
PMCID: PMC11413077
DOI: 10.1007/s00595-024-02827-9

Abstract

Purpose: This study investigated the impact of sidedness of colorectal cancer (CRC) in elderly patients on the prognosis.

Methods: In a sub-analysis of a multicenter case-control study of CRC patients who underwent surgery at ≥ 80 years old conducted in Japan between 2003 and 2007, both short- and long-term outcomes were compared between right-sided colon cancers (RCCs) and left-sided colorectal cancers (LCCs). RCCs were defined as those located from the cecum to the transverse colon.

Results: Among the 1680 patients who underwent curative surgery, 812 and 868 had RCCs and LCCs, respectively. RCCs were more frequent than LCCs in those who were female, had renal comorbidities, and had a history of abdominal surgery. Regarding tumor characteristics, RCCs were larger, invaded more deeply, and were diagnosed as either mucinous or signet ring-cell carcinoma more frequently than LCCs. Regarding the prognosis, patients with RCCs had a significantly longer cancer-specific survival (CS-S) and cancer-specific relapse-free survival (CS-RFS) than those with LCCs. Furthermore, sidedness was determined to be an independent prognostic factor for CS-S and CS-RFS.

Conclusion: RCCs, which accounted for half of the cases in patients ≥ 80 years old, showed better long-term outcomes than LCCs.

Keywords: Colorectal cancer; Elderly patients; Laparoscopic; Open; Sidedness.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

**Fig. 1**
Patients and inclusion criteria for the data analysis relating to tumor location divided into right- and left-side cases for patients ≥ 80 years old in this study

**Fig. 2**
The comparison of survival outcomes between right- and left-sided colorectal cancers (pathological stage II–III). The overall survival (A), relapse-free survival (B), cancer-specific survival (C), and cancer-specific relapse-free survival (D). The data were summarized as hazard ratios (HRs) with 95% confidence intervals (CIs) and p-values based on a log-rank test

See this image and copyright information in PMC

References

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1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J cancer. 2015;134:E359–86. - PubMed
1. Yamamoto S, Hinoi T, Niitsu H, Okajima M, Ide Y, Murata K, et al. Influence of previous abdominal surgery on surgical outcomes between laparoscopic and open surgery in elderly patients with colorectal cancer: subanalysis of a large multicenter study in Japan. J Gastroenterol. 2017;52:695–704. - PubMed
1. Hinoi T, Kawaguchi Y, Hattori M, Okajima M, Ohdan H, Yamamoto S, et al. Laparoscopic versus open surgery for colorectal cancer in elderly patients: a multicenter matched case-control study. Ann Surg Oncol. 2015;22:2040–50. - PubMed
1. Niitsu H, Hinoi T, Kawaguchi Y, Ohdan H, Hasegawa H, Suzuka I, et al. Laparoscopic surgery for colorectal cancer is safe and has survival outcomes similar to those of open surgery in elderly patients with a poor performance status: subanalysis of a large multicenter case–control study in Japan. J Gastroenterol. 2016;51:43–54. - PubMed

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Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan

Collaborators

Affiliations

Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical