Retraction Note: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

William M Armstead^{1

2}, Hugh Hekierski³, Philip Pastor³, Serge Yarovoi⁴, Abd Al-Roof Higazi^{4

5}, Douglas B Cines⁴

Affiliations

¹ Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, JM319104, USA. armsteaw@uphs.upenn.edu.
² Pharmacology, University of Pennsylvania, Philadelphia, PA, 19104, USA. armsteaw@uphs.upenn.edu.
³ Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, JM319104, USA.
⁴ Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁵ Department of Clinical Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

William M Armstead et al. Transl Stroke Res. 2025 Aug.

. 2025 Aug;16(4):1445.

doi: 10.1007/s12975-024-01264-7. Epub 2024 Jun 6.

William M Armstead^{1

2}, Hugh Hekierski³, Philip Pastor³, Serge Yarovoi⁴, Abd Al-Roof Higazi^{4

5}, Douglas B Cines⁴

¹ Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, JM319104, USA. armsteaw@uphs.upenn.edu.
² Pharmacology, University of Pennsylvania, Philadelphia, PA, 19104, USA. armsteaw@uphs.upenn.edu.
³ Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, JM319104, USA.
⁴ Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁵ Department of Clinical Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

No abstract available

Retraction of

1. Armstead WM, Hekierski H, Yarovoi S, Higazi AA-R, Cines DB. tPA variant tPA-A^296–299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1. J Neuro Res. 2018;96:128–37. https://doi.org/10.1002/jnr.24112 . - DOI
1. Curvello V, Pastor P, Hekierski H, et al. Retracted article: inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs. Neurocrit Care. 2019;30:467–77. https://doi.org/10.1007/s12028-018-0638-1 . - DOI - PubMed
1. Curvello V, Pastor P, Hekierski H, et al. Retraction Note: Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs. Neurocrit Care. 2023;38:219. https://doi.org/10.1007/s12028-022-01640-x . - DOI - PubMed