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. 1985 Jan 15;225(2):523-7.
doi: 10.1042/bj2250523.

Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding

G van de Werve, J Proietto, B Jeanrenaud

Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding

G van de Werve et al. Biochem J. .

Abstract

In isolated rat adipocytes, tumour-promoting phorbol esters caused (1) dose-dependent stimulation of lipogenesis in the absence of insulin and (2) inhibition of the lipogenic effect of submaximal concentrations of insulin, but without affecting insulin binding. The possible involvement of protein kinase C in insulin action is discussed.

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References

    1. Biochem Biophys Res Commun. 1979 Feb 28;86(4):1037-43 - PubMed
    1. Eur J Biochem. 1982 Dec 15;129(2):389-93 - PubMed
    1. Horm Metab Res. 1974 Jan;6(1):12-6 - PubMed
    1. Mol Cell Endocrinol. 1984 Jun;36(1-2):123-9 - PubMed
    1. Biochim Biophys Acta. 1974 Jan 23;337(1):41-9 - PubMed

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