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Review
. 2025 Jan;132(1):1-10.
doi: 10.1038/s41416-024-02672-0. Epub 2024 Jun 5.

Gastrointestinal stromal tumour (GIST): British Sarcoma Group clinical practice guidelines

Ian Judson  1 , Robin L Jones  2 , Newton A C S Wong  3 , Palma Dileo  4 , Ramesh Bulusu  5 , Myles Smith  2 , Max Almond  6
Affiliations
Review

Gastrointestinal stromal tumour (GIST): British Sarcoma Group clinical practice guidelines

Ian Judson et al. Br J Cancer. 2025 Jan.

Abstract

Background: British Sarcoma Group guidelines for the management of GIST were initially informed by those published by the European Society of Clinical Oncology. This update was written by a group of experts to includes a discussion of the highlight improvements in our knowledge of the disease and recent treatment developments. The guidelines include sections on Incidence, Aetiology, Diagnosis, including risk assessment, Treatment and Follow-up.

Methods: A careful review of the literature was performed to ensure that wherever possible recommendations are supported by the results of clinical trials or substantive retrospective reports. Areas of uncertainty are indicated appropriately.

Conclusion: Guidelines represent a consensus view of current best clinical practice. Where appropriate, key recommendations are given and the levels of evidence and strength of recommendation gradings are those used by the European Society for Medical Oncology (ESMO).

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Conflict of interest statement

Competing interests: The following authors reported no competing interests: IJ, MA, NW. The following received honoraria from Deciphera for attendance at advisory boards etc: MS, PD, RB and RJ. RB also received honoraria from Blueprint. RJ also reports receipt of grants from MSD and GSK and consultation fees from Adaptimmune, Astex, Athenex, Bayer, Boehringer Ingelheim, Blueprint, Clinigen, Eisai, Epizyme, Daichii, Immunedesign, Immunicum, Karma Oncology, Lilly, Merck, Mundipharma, Pharmamar, Springworks, SynOx, Tracon, UptoDate.

Figures

Fig. 1
Fig. 1. Algorithm indicating a sequential decision-making tool for molecular testing of newly diagnosed GIST.
Note that imatinib 800 mg for KIT exon 9 mutant GIST and avapritinib for PDGFR exon 18 D842V mutant GIST are not approved by NICE.
See this image and copyright information in PMC

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