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. 2024 May 22:15:1367621.
doi: 10.3389/fendo.2024.1367621. eCollection 2024.

Diastolic and systolic blood pressure and gout: a Mendelian randomization study

Yanfang Li #  1   2 , Yufeng Xie #  1   2   3 , Jun Li  1   2 , Zhichun Chang  1   2 , Jianmei Zhang  1   2 , Zunming Zhou  2 , Rong Ren  2 , Yun Chen  2
Affiliations

Diastolic and systolic blood pressure and gout: a Mendelian randomization study

Yanfang Li et al. Front Endocrinol (Lausanne). .

Abstract

Background: Although there is solid epidemiological evidence supporting the connection between hypertension and gout, little has been said about the relationship between diastolic and systolic blood pressure and gout, the causal relationship and direction associated are uncertain, so we aim to research the causal relationship between diastolic and systolic blood pressure and gout.

Methods: We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal effect between 2 blood pressure phenotypes (including diastolic blood pressure and systolic blood pressure) and 5 gout phenotypes (including gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout) using genome-wide association study statistics. The inverse variance weighting method was used to generate the main results, while sensitivity analyses using MR-Egger, weighted median, Cochran's Q test, Egger intercept test, and leave-one-out analysis, were performed to assess the stability and reliability of the results.

Results: After the screening, we found a causal relationship between diastolic blood pressure and gout, idiopathic gout, unspecified gout, and strictly defined gout, and a causal relationship between systolic blood pressure and gout, idiopathic gout, unspecified gout, and strictly defined gout.

Conclusion: From a genetic predisposition, controlling blood pressure may reduce the risk of gout.

Keywords: Mendelian randomization; causality; diastolic and systolic blood pressure; gout; two-sample.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Forest plot for the causal effect of diastolic and systolic blood pressure on the risk of gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout derived from inverse variance weighted (IVW). OR, odds ratio; CI, confidence interval.
Figure 2
Figure 2
Scatter plot for the significant Mendelian randomization (MR) association between diastolic blood pressure and gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout; systolic blood pressure and gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout. SNP, single nucleotide polymorphism.
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