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Comment
. 2024 Jun 18;121(25):e2408794121.
doi: 10.1073/pnas.2408794121. Epub 2024 Jun 6.

SARS-CoV-2 Nsp1 traps RNA in the nucleus to escape immune detection

Jaresley V Guillen  1 , Britt A Glaunsinger  1   2   3
Affiliations
Comment

SARS-CoV-2 Nsp1 traps RNA in the nucleus to escape immune detection

Jaresley V Guillen et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
A simplified schematic showing the role of NXF1-NXT1 in the transport of mRNA from the nucleus to the cytoplasm (Left) and the effect of SARS-CoV-2 Nsp1 protein on mRNA export, translation, and stability (Right). Nsp1 binds the 40S ribosomal subunit at the mRNA entry channel via its helical C-terminal domain, which results in translation inhibition and subsequent mRNA degradation. The N-terminal domain of Nsp1 binds NXF1 to block nuclear export of mRNA.
See this image and copyright information in PMC

Comment on

  • Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis.
    Mei M, Cupic A, Miorin L, Ye C, Cagatay T, Zhang K, Patel K, Wilson N, McDonald WH, Crossland NA, Lo M, Rutkowska M, Aslam S, Mena I, Martinez-Sobrido L, Ren Y, García-Sastre A, Fontoura BMA. Mei M, et al. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2314166121. doi: 10.1073/pnas.2314166121. Epub 2024 May 20. Proc Natl Acad Sci U S A. 2024. PMID: 38768348 Free PMC article.

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