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. 2024 Jun 5:79:100396.
doi: 10.1016/j.clinsp.2024.100396. eCollection 2024.

Acute viral bronchiolitis phenotype in response to glucocorticoid and bronchodilator treatment

Andressa Roberta Paschoarelli Chacorowski  1 , Vanessa de Oliveira Lima  2 , Eniuce Menezes  2 , Jorge Juarez Vieira Teixeira  2 , Dennis Armando Bertolini  2
Affiliations

Acute viral bronchiolitis phenotype in response to glucocorticoid and bronchodilator treatment

Andressa Roberta Paschoarelli Chacorowski et al. Clinics (Sao Paulo). .

Abstract

Objective: To analyze whether infants admitted to hospital with Acute Viral Bronchiolitis (AVB), who received glucocorticoids and bronchodilators, and who had an atopic phenotype, spent less time in hospital and/or less time on oxygen therapy when compared to those who did not have the phenotype.

Method: A cross-sectional, retrospective epidemiological study was developed with data from medical records of infants admitted to hospital due to AVB from 2012 to 2019 in a sentinel public hospital. It was verified that the frequency of prescription of glucocorticoids, bronchodilators and antibiotics. Length of stay and oxygen therapy duration were then compared in the group that used glucocorticoids and bronchodilators between those who had a personal or family history of atopy and those who did not. Subsequently, the length of hospital stay was compared among infants who received antibiotic therapy and those who did not.

Results: Fifty-eight infants were included. Of these, 62.1 % received an antibiotic, 100 % a bronchodilator and 98.3 % a glucocorticoid. When comparing infants without a family history of atopy, those who received antibiotics had a longer hospital stay (p = 0.01).

Conclusion: The presence of an atopic phenotype did not interfere with the length of stay and/or oxygen therapy duration of those who received bronchodilators and glucocorticoids. Increased length of stay of infants without a family history of atopy, who used antibiotics without evidence of bacterial co-infection, and the high frequency of prescription of non-recommended drugs call attention to stricter protocol implementation and professional training in AVB diagnosis and care.

Keywords: Bronchiolitis; Bronchodilator; Glucocorticoid; Phenotype; Respiratory syncytial virus; Treatment.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

Figures

Fig 1
Fig 1
Excluded infant flowchart. *Other diagnoses: pneumonia (questioned or confirmed), chronic lung disease, genetic syndromes, neuropathy, heart disease, pertussis syndrome, and suspected tuberculosis.
See this image and copyright information in PMC

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