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. 1985 Apr;54(4):745-54.

The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies

R A de Maagd, W A MacKenzie, H J Schuurman, M A Ritter, K M Price, R Broekhuizen, L Kater

The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies

R A de Maagd et al. Immunology. 1985 Apr.

Abstract

Monoclonal antibodies were raised against human thymus stromal cells and their specificity for the epithelial component of thymus stroma assessed by double immunofluorescence using anti-keratin antibodies to identify epithelium. Our monoclonal antibodies identify six distinct patterns of epithelial cell antigen expression within the thymus: pan epithelial (antibody IP1); cortex (MR3 and MR6); cortical/medullary junction (IP2); subcapsule and subpopulation of medulla (MR10/MR14); Hassall's corpuscles and adjacent subpopulation of medulla (IP3); Hassall's corpuscles only (MR13/IP4). This heterogeneity of antigen expression suggests that many different epithelial microenvironments exist within the human thymus.

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