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. 2024 Jun 6;6(1):30.
doi: 10.1186/s42466-024-00325-4.

Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology)

Günter Höglinger  1   2   3 ; German Parkinson’s Guidelines Committee; Claudia Trenkwalder  4
Collaborators, Affiliations

Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology)

Günter Höglinger et al. Neurol Res Pract. .

Abstract

Introduction: The aim of this German national guideline is to optimize the clinical care of patients with Parkinson's disease (PD) in terms of diagnostics, drug and surgical treatment and care. This guidance was prepared for the German Society of Neurology (DGN) in collaboration with the Austrian Society of Neurology (ÖGN) and the Swiss Neurological Society (SNG) for German-speaking countries. The guidelines for the diagnosis and treatment of PD have been revised by a national expert group and the guideline commission of the DGN at S2k level. The main objective of these guidelines is to optimize the clinical care of PD patients regarding diagnosis, including early detection, technical diagnostic examinations, and pharmacological as well as invasive treatment options.

Recommendations: The updated PD diagnosis and treatment guidelines are emphasizing optimized clinical care. Key revisions include preferring the name "Parkinson's disease" over previous terms and adopting International Parkinson and Movement Disorder Society (MDS) diagnostic criteria. Recommendations cover genetic and imaging diagnostics, initial pharmacotherapy considering efficacy and patient factors, and tailored pharmacological combinations for complications. Guidelines extend to managing cognitive, affective, psychotic, and autonomic symptoms, along with non-oral therapies like pump therapy and deep brain stimulation. Special situations like akinetic crisis, driving ability, and care concepts are addressed, ensuring comprehensive management for PD patients at various stages and conditions.

Conclusions: This guidance reflects the state of the art at the beginning of 2024.

Keywords: Care; Diagnosis; Parkinson’s disease; Treatment.

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Conflict of interest statement

Günter Höglinger has ongoing research collaborations with Roche, UCB, Abbvie; served as a consultant for Abbvie, Alzprotect, Amylyx, Aprinoia, Asceneuron, Bayer, Bial, Biogen, Biohaven, Epidarex, Ferrer, Kyowa Kirin, Lundbeck, Novartis, Retrotope, Roche, Sanofi, Servier, Takeda, Teva, UCB; received honoraria for scientific presentations from Abbvie, Bayer, Bial, Biogen, Bristol Myers Squibb, Esteve, Kyowa Kirin, Pfizer, Roche, Teva, UCB, Zambon; received publication royalties from Academic Press, Kohlhammer, Springer and Thieme; all without relevant impact on the guidelines and this article.

Claudia Trenkwalder is Section Editor for Neurological Research and Practice.

Figures

Fig. 1
Fig. 1
Treatment algorithm for pain in PD patients; nociceptive pain according to WHO three-step-pain treatment scheme (adapted with permission from [5])
See this image and copyright information in PMC

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