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. 2024 Mar 8:9:e47-e55.
doi: 10.5114/amsad/184701. eCollection 2024.

Characteristics and clinical outcomes of patients with sarcoidosis admitted for ST-elevation myocardial infarction in the United States: a propensity matched analysis from the National Inpatient Sample

Raheel Ahmed  1   2 , Noem Najam  3 , Kamleshun Ramphul  4 , Sebastian Mactaggart  5 , Mansimran Sigh Dulay  1 , Joseph Okafor  1 , Alessia Azzu  1 , Maham Bilal  3 , Rahat A Memon  6 , Hemamalini Sakthivel  7 , Rajdeep Khattar  1 , Athol Umfrey Wells  1 , John Arun Baksi  1 , Kshama Wechalekar  1 , Vasilis Kouranos  1 , Anwar Chahal  8   9   10 , Rakesh Sharma  1   2
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Characteristics and clinical outcomes of patients with sarcoidosis admitted for ST-elevation myocardial infarction in the United States: a propensity matched analysis from the National Inpatient Sample

Raheel Ahmed et al. Arch Med Sci Atheroscler Dis. .

Abstract

Introduction: Sarcoidosis is a systemic inflammatory disorder characterised by non-caseating granulomas. Cardiac sarcoidosis (CS) normally causes conduction abnormalities, ventricular arrhythmias, and heart failure. Little is known about the characteristics and impact of sarcoidosis in patients admitted with ST-elevation myocardial infarction (STEMI). This study aims to fill this void.

Material and methods: Utilising the National Inpatient Sample (NIS) database (2016-2020), individuals with STEMI were identified and categorised based on sarcoidosis presence whilst adjusting for confounders via logistic regression models.

Results: Among 851,290 STEMI patients, 1215 had sarcoidosis. Before propensity matching, sarcoidosis patients were notably different in demographics and comorbidities compared to non-sarcoidosis patients. After propensity score matching (PSM), sarcoidosis patients were found to have a higher incidence of supraventricular tachycardia (SVT) (2.5% vs. 1.3%, p = 0.024) and acute kidney injury (AKI) (23.3% vs. 20.8%, aOR = 1.269, 95% CI: 1.02-1.58, p = 0.033) but a lower incidence of undergoing coronary artery bypass graft (CABG) (5.5% vs. 8.5%, aOR = 0.663; 95% CI: 0.472-0.931, p = 0.018), while no significant disparities were noted in PCI, cardiogenic shock, mortality, or mean length of stay (LOS).

Conclusions: Using propensity-matched large real-world data of STEMI patients, sarcoidosis was associated with fewer cases of CABG and a greater incidence of AKI and SVT compared to non-sarcoidosis patients.

Keywords: ST-elevation myocardial infarction; cardiac sarcoidosis; propensity matched; sarcoidosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Adjusted odds ratio of events in patients with and without sarcoidosis (reference) admitted for STEMI in the United States
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