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Meta-Analysis
. 2024 Jun 7;19(6):e0301859.
doi: 10.1371/journal.pone.0301859. eCollection 2024.

A meta-analysis of the association between inflammatory cytokine polymorphism and neonatal sepsis

Jiaojiao Liang  1 , Yan Su  1 , Na Wang  1 , Xiaoyan Wang  1 , Ling Hao  1 , Changjun Ren  1
Affiliations
Meta-Analysis

A meta-analysis of the association between inflammatory cytokine polymorphism and neonatal sepsis

Jiaojiao Liang et al. PLoS One. .

Abstract

Objective: The purpose of this study is to investigate the relationship between single nucleotide polymorphisms of inflammatory cytokines and neonatal sepsis through meta-analysis.

Methods: We collected research literature on the correlation between inflammatory cytokine polymorphisms and neonatal sepsis published before August 2023 through computer searches of databases such as PubMed, Embase, etc. The Stata 14.0 software was utilized for Meta-analysis. To assess heterogeneity, the chi-squared Q-test and I2 statistics were used. The Egger and Begg tests were conducted to determine the possibility of publication bias.

Results: After reviewing 1129 articles, 29 relevant articles involving 3348 cases and 5183 controls were included in the study. The meta-analysis conducted on IL-1βrs1143643 polymorphism revealed significant findings: the T allele genotype has a lower risk of neonatal sepsis(P = 0.000, OR = 0.224, 95% CI: 0.168-0.299), while the TC and TT genotypes showed an increased risk(TC: P = 0.000,OR = 4.251, 95% CI: 2.226-8.119; TT: P = 0.019,OR = 2.020, 95% CI: 1.122-3.639). Similarly, newborns with the IL-6-174 CC genotype had a significantly higher risk of sepsis(P = 0.000,OR = 1.591, 95% CI: 1.154-2.194), while those with the IL-8-rs4073 TT (P = 0.003,OR = 0.467, 95% CI: 0.280-0.777)and TT + AA(P = 0.003,OR = 0.497, 95% CI: 0.315-0.785) genotypes had a significantly lower risk of sepsis. For the IL-10-1082 gene, newborns with the AA genotype(P = 0.002,OR = 1.702, 95% CI: 1.218-2.377), as well as those with the AA + GA genotype(P = 0.016,OR = 1.731, 95% CI: 1.108-2.705), had a significantly higher risk of sepsis. Lastly, newborns carrying the TNF-α-308 A allele (P = 0.016,OR = 1.257, 95% CI: 1.044-1.513)or the AA genotype(P = 0.009,OR = 1.913, 95% CI: 1.179-3.10) have a significantly increased risk of sepsis. Notwithstanding, additional studies must be included for validation. Applying these cytokines in clinical practice and integrating them into auxiliary examinations facilitates the early detection of susceptible populations for neonatal sepsis, thereby providing a new diagnostic and therapeutic approach for neonatal sepsis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart of IL-1 literature screening.
Fig 2
Fig 2. Flow chart of IL-6 literature screening.
Fig 3
Fig 3. Flow chart of IL-8 literature screening.
Fig 4
Fig 4. Flow chart of IL-10 literature screening.
Fig 5
Fig 5. Flow chart of TNF-α literature screening.
Fig 6
Fig 6. TSA map of IL-1 allele.
Fig 7
Fig 7. TSA map of IL-1 dominant gene.
Fig 8
Fig 8. TSA map of IL-1 recessive gene.
Fig 9
Fig 9. TSA map of IL-1 heterozygous gene.
Fig 10
Fig 10. TSA map of IL-1 homozygous gene.
Fig 11
Fig 11. TSA map of IL-1 additive gene.
Fig 12
Fig 12. TSA map of IL-6 allele.
Fig 13
Fig 13. TSA map of IL-6 dominant gene.
Fig 14
Fig 14. TSA map of IL-6 heterozygous gene.
Fig 15
Fig 15. TSA map of IL-6 additive gene.
Fig 16
Fig 16. TSA map of IL-6 recessive gene.
Fig 17
Fig 17. TSA map of IL-6 homozygous gene.
Fig 18
Fig 18. TSA map of IL-8 allele.
Fig 19
Fig 19. TSA map of IL-8 dominant gene.
Fig 20
Fig 20. TSA map of IL-8 recessive gene.
Fig 21
Fig 21. TSA map of IL-8 additive gene.
Fig 22
Fig 22. TSA map of IL-8 heterozygous gene.
Fig 23
Fig 23. TSA map of IL-8 homozygous gene.
Fig 24
Fig 24. TSA map of IL-10 allele.
Fig 25
Fig 25. TSA map of IL-10 dominant gene.
Fig 26
Fig 26. TSA map of IL-10 homozygous gene.
Fig 27
Fig 27. TSA map of IL-10 recessive gene.
Fig 28
Fig 28. TSA map of IL-10 heterozygous gene.
Fig 29
Fig 29. TSA map of IL-10 additive gene.
Fig 30
Fig 30. TSA map of TNF-α allele.
Fig 31
Fig 31. TSA map of TNF-α recessive gene.
Fig 32
Fig 32. TSA map of TNF-α dominant gene.
Fig 33
Fig 33. TSA map of TNF-α heterozygous gene.
Fig 34
Fig 34. TSA map of TNF-α homozygous gene.
Fig 35
Fig 35. TSA map of TNF-α additive gene.
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