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Review
. 2024 Aug;34(8):622-625.
doi: 10.1016/j.tcb.2024.05.004. Epub 2024 Jun 6.

Lysosomal control of the cGAS-STING signaling

Yinfeng Xu  1 , Wei Wan  2
Affiliations
Review

Lysosomal control of the cGAS-STING signaling

Yinfeng Xu et al. Trends Cell Biol. 2024 Aug.

Abstract

The cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway has a crucial role in combating pathogen infection. However, its aberrant activation is involved in several human disorders. Lysosomes are emerging as key negative regulators of cGAS-STING signaling. Here, we discuss the lysosomal control of cGAS-STING signaling and its implication in human disorders.

Keywords: STING; autophagy; cGAS; human disorders; innate immunity; lysosome.

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Conflict of interest statement

Declaration of interests No interests are declared.

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