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. 2024 Jun 7;24(1):83.
doi: 10.1186/s12902-024-01616-2.

Correlation of serum Meteorin-like (Metrnl) level with type 2 diabetic peripheral neuropathy

Caixia Yao  1   2 , Hongman Zhang  1   3 , Li Wang  1 , Jianbo Li  4
Affiliations

Correlation of serum Meteorin-like (Metrnl) level with type 2 diabetic peripheral neuropathy

Caixia Yao et al. BMC Endocr Disord. .

Abstract

Objective: Meteorin-like (Metrnl), a secreted myokine, is a newly discovered neurotrophic factor. The aim of this study was to determine if there is a correlation between the Metrnl level and diabetic peripheral neuropathy (DPN).

Methods: The investigation was conducted on a sample of 80 patients with type 2 diabetes mellitus (T2DM) and 60 healthy controls. The T2DM patients were categorized into two subgroups based on skin biopsy: the DPN subgroup (n = 20) and the diabetes without neuropathy subgroup (n = 60).

Results: The T2DM groups had higher serum Metrnl concentrations compared with the controls. The serum Metrnl concentration was significantly lower in the DPN group than in T2DM patients without neuropathy. Logistic regression analysis demonstrated a notable correlation between serum Metrnl and DPN (OR: 0.997, 95% CI: 0.995-1.000, P < 0.05). Serum Metrnl level was negatively correlated with age and SBP after a simple logistic regression analysis.

Conclusion: Serum Metrnl concentration is independently correlated with DPN.

Keywords: Diabetic peripheral neuropathy; Meteorin-like; Type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Small nerve fibers in the skin tissue of patients evaluated using PGP9.5 staining. NC, normal control; DPN, diabetic peripheral neuropathy; PGP9.5, protein gene product 9.5. The white arrows show the counted nerve fibers
Fig. 2
Fig. 2
Serum Metrnl levels in T2DM patients and healthy controls. The diabetes without neuropathy subgroup showed significantly increased serum Metrnl concentrations compared with the control group. The serum Metrnl concentrations were significantly lower in the diabetes with neuropathy group compared with the DM group
See this image and copyright information in PMC

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