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Review
. 2024 Jun 8;29(1):317.
doi: 10.1186/s40001-024-01918-0.

The brain-bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism

Haojun Shi  1 , Min Chen  2
Affiliations
Review

The brain-bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism

Haojun Shi et al. Eur J Med Res. .

Abstract

The brain-bone axis has emerged as a captivating field of research, unveiling the intricate bidirectional communication between the central nervous system (CNS) and skeletal metabolism. This comprehensive review delves into the current state of knowledge surrounding the brain-bone axis, exploring the complex mechanisms, key players, and potential clinical implications of this fascinating area of study. The review discusses the neural regulation of bone metabolism, highlighting the roles of the sympathetic nervous system, hypothalamic neuropeptides, and neurotransmitters in modulating bone remodeling. In addition, it examines the influence of bone-derived factors, such as osteocalcin and fibroblast growth factor 23, on brain function and behavior. The therapeutic potential of targeting the brain-bone axis in the context of skeletal and neurological disorders is also explored. By unraveling the complex interplay between the CNS and skeletal metabolism, this review aims to provide a comprehensive resource for researchers, clinicians, and students interested in the brain-bone axis and its implications for human health and disease.

Keywords: Bone-derived factors; Brain–bone axis; Neuropeptides; Neurotransmitters.

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Conflict of interest statement

The authors declare there are no competing interests.

Figures

Fig. 1
Fig. 1
The leptin–hypothalamus–SNS–bone axis
See this image and copyright information in PMC

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