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Review
. 2024 Jun 8;19(1):22.
doi: 10.1186/s13017-024-00552-9.

Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery

Massimo Sartelli  1 , Philip Barie  2 , Vanni Agnoletti  3 , Majdi N Al-Hasan  4 , Luca Ansaloni  5 , Walter Biffl  6 , Luis Buonomo  7 , Stijn Blot  8 , William G Cheadle  9 , Raul Coimbra  10   11 , Belinda De Simone  12 , Therese M Duane  13 , Paola Fugazzola  5 , Helen Giamarellou  14 , Timothy C Hardcastle  15 , Andreas Hecker  16 , Kenji Inaba  17 , Andrew W Kirkpatrick  18 , Francesco M Labricciosa  19 , Marc Leone  20 , Ignacio Martin-Loeches  21   22   23   24 , Ronald V Maier  25 , Sanjay Marwah  26 , Ryan C Maves  27 , Andrea Mingoli  28 , Philippe Montravers  29 , Carlos A Ordóñez  30 , Miriam Palmieri  31 , Mauro Podda  32 , Jordi Rello  33   34 , Robert G Sawyer  35 , Gabriele Sganga  36 , Pierre Tattevin  37 , Dipendra Thapaliya  38 , Jeffrey Tessier  39 , Matti Tolonen  40 , Jan Ulrych  41 , Carlo Vallicelli  42 , Richard R Watkins  43 , Fausto Catena  42 , Federico Coccolini  44
Affiliations
Review

Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery

Massimo Sartelli et al. World J Emerg Surg. .

Abstract

Intra-abdominal infections (IAIs) are an important cause of morbidity and mortality in hospital settings worldwide. The cornerstones of IAI management include rapid, accurate diagnostics; timely, adequate source control; appropriate, short-duration antimicrobial therapy administered according to the principles of pharmacokinetics/pharmacodynamics and antimicrobial stewardship; and hemodynamic and organ functional support with intravenous fluid and adjunctive vasopressor agents for critical illness (sepsis/organ dysfunction or septic shock after correction of hypovolemia). In patients with IAIs, a personalized approach is crucial to optimize outcomes and should be based on multiple aspects that require careful clinical assessment. The anatomic extent of infection, the presumed pathogens involved and risk factors for antimicrobial resistance, the origin and extent of the infection, the patient's clinical condition, and the host's immune status should be assessed continuously to optimize the management of patients with complicated IAIs.

Keywords: Antimicrobial resistance; Antimicrobial therapy; Intra-abdominal infections; Source control.

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Conflict of interest statement

A.W.K. serves as the PI of the COOL trial, which previously was partially supported by the 3 M/Acelity Corporation until Aug 2022. A.W.K. is also a member of the Canadian Forces Medical Services and has consulted for the 3 m/Acelity Corporation, Zoll Medical, Innovative Trauma Care, and CSL Behring. A.W.K. is the Director of the TeleMentored Ultrasound Supported Medical Interventions (TMUSMI) Research group and serves in the Canadian Forces Medical Services.R.G.S conflicts are on Data Management and Safety Board for Advarra.R.C.M. received research support (paid to Institution) from AiCuris, GeoVax and Biotest. He received honoraria for participation in a scientific advisory board organized by Shionogi.All the other authors declare that they have no competing interests. R.G.S conflicts are on Data Management and Safety Board for Advarra. R.C.M. received research support (paid to Institution) from AiCuris, GeoVax and Biotest. He received honoraria for participation in a scientific advisory board organized by Shionogi. All the other authors declare that they have no competing interests.

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