Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 Mar;82(6):1822-6.
doi: 10.1073/pnas.82.6.1822.

Relationship of M protein genes in group A streptococci

J R Scott, W M Pulliam, S K Hollingshead, V A Fischetti
Comparative Study

Relationship of M protein genes in group A streptococci

J R Scott et al. Proc Natl Acad Sci U S A. 1985 Mar.

Abstract

The M protein of group A streptococci is considered one of the primary virulence determinants of this organism because it prevents phagocytosis. All of the 56 different M protein types of group A streptococci tested contain a DNA region that hybridizes with a labeled probe consisting of DNA encoding the type 6 M protein (emm6 gene). In addition, 2 of 3 functionally M- group A strains (strains that are successfully phagocytized) also contain this gene, but this DNA is not present in 1 M- strain. Of the other streptococcal groups, only groups C and G, which are closely related to group A, contain DNA that hybridizes with emm6. None of the non-streptococcal Gram-positive bacteria tested contains emm6-related DNA. In the strain from which emm6 was cloned, there appears to be only a single copy of this gene.

PubMed Disclaimer

References

    1. J Gen Microbiol. 1967 Oct;49(1):119-25 - PubMed
    1. J Immunol. 1968 Jan;100(1):39-45 - PubMed
    1. J Immunol. 1969 Aug;103(2):149-54 - PubMed
    1. J Exp Med. 1969 Nov 1;130(5):1063-91 - PubMed
    1. J Exp Med. 1971 May 1;133(5):1105-17 - PubMed

Publication types

Associated data

LinkOut - more resources