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. 2025 Feb;54(2):209-217.
doi: 10.1007/s00256-024-04721-4. Epub 2024 Jun 9.

Diagnostic performance and inter-reader reliability of bone reporting and data system (Bone-RADS) on computed tomography

Chankue Park  1   2   3 , Arash Azhideh  2   3 , Atefe Pooyan  2   3 , Ehsan Alipour  2   3 , Sara Haseli  2   3 , Ishan Satwah  4 , Majid Chalian  5   6
Affiliations

Diagnostic performance and inter-reader reliability of bone reporting and data system (Bone-RADS) on computed tomography

Chankue Park et al. Skeletal Radiol. 2025 Feb.

Abstract

Objective: To evaluate the diagnostic performance and inter-reader reliability of the Bone Reporting and Data System (Bone-RADS) for solitary bone lesions on CT.

Materials and methods: This retrospective analysis included 179 patients (mean age, 56 ± 18 years; 94 men) who underwent bone biopsies between March 2005 and September 2021. Patients with solitary bone lesions on CT and sufficient histopathology results were included. Two radiologists categorized the bone lesions using the Bone-RADS (1, benign; 4, malignant). The diagnostic performance of the Bone-RADS was calculated using histopathology results as a standard reference. Inter-reader reliability was calculated.

Results: Bone lesions were categorized into two groups: 103 lucent (pathology: 34 benign, 12 intermediate, 54 malignant, and 3 osteomyelitis) and 76 sclerotic/mixed (pathology: 46 benign, 2 intermediate, 26 malignant, and 2 osteomyelitis) lesions. The Bone-RADS for lucent lesions had sensitivities of 95% and 82%, specificities of 11% and 11%, and accuracies of 57% and 50% for readers 1 and 2, respectively. The Bone-RADS for sclerotic/mixed lesions had sensitivities of 75% and 68%, specificities of 27% and 27%, and accuracies of 45% and 42% for readers 1 and 2, respectively. Inter-reader reliability was moderate to very good (κ = 0.744, overall; 0.565, lucent lesions; and 0.851, sclerotic/mixed lesions).

Conclusion: Bone-RADS has a high sensitivity for evaluating malignancy in lucent bone lesions and good inter-reader reliability. However, it has poor specificity and accuracy for both lucent and sclerotic/mixed lesions. A possible explanation is that proposed algorithms heavily depend on clinical features such as pain and history of malignancy.

Keywords: Bone tumor; Bone-RADS; CT; Performance; Reliability.

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