Linking IL-6 and hsCRP among Indian patients with myocardial infarction

Abstract

The association between serum interleukin-6 (IL-6) and highly sensitive C - reactive protein (hsCRP) as predictors of the risk factors for Myocardial Infarction. The study included a total of 50 patients with Myocardial Infarction, aged between 25 to 74 years. The levels of hsCRP were measured using the immunoturbidimetry method, while Interleukin 6 was estimated using the sandwich ELISA method. Statistical analysis was conducted using SPSS version 21.0, with p values calculated using Quartile ratio, ANOVA unpaired t-test, and Kaplan-Meier Curve Method. A p-value of less than 0.05 was considered statistically significant. All participants underwent a questionnaire, physical examination, medical history assessment, and laboratory tests. The results of the study showed that there was a significant correlation between IL-6 and hsCRP levels in the Quartile groups, as well as with lipid profiles. The Kaplan-Meier method also demonstrated a significant association between IL-6 and hsCRP levels in participants. The comparison of biomarkers further supported these findings. Thus, data shows that elevated levels of hsCRP and IL-6 could serve as valuable diagnostic markers for predicting Acute Myocardial Infarction. Our study strongly suggests that IL-6 could be a powerful marker in evaluating the Myocardial Infarction.

Keywords: Acute Coronary Syndrome; Biochemical Marker; Interleukin-6; Myocardial infarction; high sensitivity C- reactive protein.

Figure 1

Kaplan-Meier curve for Hazard function analysis for risk factor associated to MI by IL-6 quartile group; analysis was carried out using SPSS version 21 software

Figure 2

Kaplan-Meier curve for Hazard function analysis for risk factor associated to MI by hs-CRP quartile group; analysis was carried out using SPSS version 21 software