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. 2024 Jun 4:17:3617-3628.
doi: 10.2147/JIR.S460610. eCollection 2024.

The Clinical Value of the Neutrophil-to-Lymphocyte Ratio, the C-Reactive Protein-to-Albumin Ratio, the Systemic Inflammatory Index, and the Systemic Inflammatory Response Index in Patients with the Anti-Synthetase Syndrome

Liuyi Huang #  1 , Xi Li #  1 , Wei Zhou  1 , Haiqing Zhu  1 , Yuehong Lao  1 , Xiaoxia Huang  1 , Zhenjia Deng  1 , Yuting Tang  1 , Jian Wang  1
Affiliations

The Clinical Value of the Neutrophil-to-Lymphocyte Ratio, the C-Reactive Protein-to-Albumin Ratio, the Systemic Inflammatory Index, and the Systemic Inflammatory Response Index in Patients with the Anti-Synthetase Syndrome

Liuyi Huang et al. J Inflamm Res. .

Abstract

Objective: There are no studies examining the role of the neutrophil-to-lymphocyte ratio (NLR), the C-reactive protein-to-albumin ratio (CAR), the systemic inflammatory index (SII), and the systemic inflammatory response index (SIRI) in anti-synthetase syndrome (ASS). We aim to compare NLR, CAR, SII, and SIRI in ASS and dermatomyositis/polymyositis (DM/PM), as well as to examine potential correlations between NLR, CAR, SII, and SIRI and clinical features and laboratory parameters in ASS.

Methods: Retrospective collection of data from 111 patients with ASS and 175 patients with DM/PM. A Spearman rank correlation analysis was utilized to analyze the correlation between NLR, CAR, SII, and SIRI and inflammatory indexes. Receiver operating characteristic (ROC) curves were used to assess the diagnostic value. Univariate logistic regression analysis was performed to assess risk factors for interstitial lung disease (ILD).

Results: Compared with DM/PM, NLR, CAR, SII, and SIRI were significantly greater in ASS patients (p < 0.05). NLR, CAR, SII, and SIRI were correlated with albumin, lactic dehydrogenase (LDH), C-reactive protein (CRP), ferritin, white blood cell (WBC), platelets, and myositis disease activity assessment visual analog scales (MYOACT) score (p < 0.05). The ROC curves analysis showed that NLR, SII, and SIRI were all highly predictive of the occurrence of ASS. Comparisons based on clinical characteristics showed elevated levels of NLR, CAR, SII, and SIRI in ASS patients with ILD, fever, and infection (p < 0.05). Univariate logistic regression analysis revealed that NLR, CAR, and SII were significant risk factors for ASS-ILD (p < 0.05).

Conclusion: The levels of NLR, CAR, SII, and SIRI were higher in ASS than in DM/PM and correlated with disease activity and specific clinical features. NLR, CAR, SII, and SIRI may be an aid in differentiating ASS from DM/PM and maybe promising biomarkers for ASS.

Keywords: anti-synthase syndrome; the C-reactive protein-to-albumin ratio; the neutrophil-to-lymphocyte ratio; the systemic immune inflammation index; the systemic inflammation response index.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart illustrating the patients that were included and excluded from the study.
Figure 2
Figure 2
Correlation between MYOACT score and NLR, CAR, SII, and SIRI in ASS.
Figure 3
Figure 3
The predictive ability of NLR, SII, SIRI, and NLR-SII-SIRI for ASS.
Figure 4
Figure 4
Comparison of NLR, CAR, SII, and SIRI according to manifestations in ASS.
Figure 5
Figure 5
ROC curve of NLR, CAR, SII, and NLR-CAR-SII for the diagnosis of ASS-ILD.
See this image and copyright information in PMC

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