Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects

doi:10.2147/JIR.S465978

Review

. 2024 Jun 5:17:3629-3639.

doi: 10.2147/JIR.S465978. eCollection 2024.

Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects

Yupeng Han^#^{1

2}, Liangcheng Qiu^#^{1

2}, Haixing Wu^#^{1

2}, Zhiwei Song³, Peng Ke^{1

2}, Xiaodan Wu^{1

2}

Affiliations

¹ Department of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
² Fujian Provincial Key Laboratory of Critical Care Medicine, Fuzhou, Fujian, People's Republic of China.
³ Department of Neurology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

^# Contributed equally.

PMID: 38855170
PMCID: PMC11162626
DOI: 10.2147/JIR.S465978

Review

Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects

Yupeng Han et al. J Inflamm Res. 2024.

. 2024 Jun 5:17:3629-3639.

doi: 10.2147/JIR.S465978. eCollection 2024.

Authors

Yupeng Han^#^{1

2}, Liangcheng Qiu^#^{1

2}, Haixing Wu^#^{1

2}, Zhiwei Song³, Peng Ke^{1

2}, Xiaodan Wu^{1

2}

Affiliations

¹ Department of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
² Fujian Provincial Key Laboratory of Critical Care Medicine, Fuzhou, Fujian, People's Republic of China.
³ Department of Neurology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

^# Contributed equally.

PMID: 38855170
PMCID: PMC11162626
DOI: 10.2147/JIR.S465978

Abstract

Sepsis is a severe systemic inflammatory response commonly occurring in infectious diseases, caused by infection with virulent pathogens. In the pathogenesis of sepsis, the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway serves a crucial role as a fundamental immunoregulatory mechanism. This signaling pathway activates STING upon recognizing intracellular DNA damage and pathogen-derived DNA, subsequently inducing the production of numerous inflammatory mediators, including interferon and inflammatory cytokines, which in turn trigger an inflammatory response. The aim of this paper is to explore the activation mechanism of the cGAS-STING signaling pathway in sepsis and its impact on inflammatory regulation. By delving into the mechanism of action of the cGAS-STING signaling pathway in sepsis, we aim to identify new therapeutic strategies for the treatment and prevention of sepsis.

Keywords: STING; cGAS; inflammation; sepsis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

**Figure 1**
Schematic diagram of cGAS STING signaling pathway mechanism.

See this image and copyright information in PMC

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[1] Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018;392(10141):75–87. doi:10.1016/S0140-6736(18)30696-2 - DOI - PubMed

[2] Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018;392(10141):75–87. doi:10.1016/S0140-6736(18)30696-2 - DOI - PubMed

[3] Seymour CW, Liu I VX, Brunkhorst TJ, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):762–774. doi:10.1001/jama.2016.0288 - DOI - PMC - PubMed

[4] Seymour CW, Liu I VX, Brunkhorst TJ, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):762–774. doi:10.1001/jama.2016.0288 - DOI - PMC - PubMed

[5] Liu D, Huang SY, Sun JH, et al. Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options. Mil Med Res. 2022;9(1):56. doi:10.1186/s40779-022-00422-y - DOI - PMC - PubMed

[6] Liu D, Huang SY, Sun JH, et al. Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options. Mil Med Res. 2022;9(1):56. doi:10.1186/s40779-022-00422-y - DOI - PMC - PubMed

[7] Huang M, Cai S, Su J. The Pathogenesis of Sepsis and Potential Therapeutic Targets. Int J Mol Sci. 2019;20(21):5376. doi:10.3390/ijms20215376 - DOI - PMC - PubMed

[8] Huang M, Cai S, Su J. The Pathogenesis of Sepsis and Potential Therapeutic Targets. Int J Mol Sci. 2019;20(21):5376. doi:10.3390/ijms20215376 - DOI - PMC - PubMed

[9] Nedeva C. Inflammation and cell death of the innate and adaptive immune system during sepsis. Biomolecules. 2021;11(7):1011. doi:10.3390/biom11071011 - DOI - PMC - PubMed

[10] Nedeva C. Inflammation and cell death of the innate and adaptive immune system during sepsis. Biomolecules. 2021;11(7):1011. doi:10.3390/biom11071011 - DOI - PMC - PubMed

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Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects

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Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects

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