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. 2024 Apr 5;15(5):2876-2889.
doi: 10.1364/BOE.512193. eCollection 2024 May 1.

Dynamic refraction and anterior segment OCT biometry during accommodation

Heather Durkee  1   2 , Marco Ruggeri  1   2 , Leana Rohman  1   2 , Siobhan Williams  1   2 , Arthur Ho  1   2   3   4 , Jean-Marie Parel  1   2   3 , Fabrice Manns  1   2
Affiliations

Dynamic refraction and anterior segment OCT biometry during accommodation

Heather Durkee et al. Biomed Opt Express. .

Abstract

Accommodation is the process by which the eye changes focus. These changes are the result of changes to the shape of the crystalline lens. Few prior studies have quantified the relation between lens shape and ocular accommodation, primarily at discrete static accommodation states. We present an instrument that enables measurements of the relation between changes in lens shape and changes in optical power continuously during accommodation. The system combines an autorefractor to measure ocular power, a visual fixation target to stimulate accommodation, and an optical coherence tomography (OCT) system to image the anterior segment and measure ocular distances. Measurements of ocular dimensions and refraction acquired dynamically on three human subjects are presented. The individual accommodative responses are analyzed to correlate the ocular power changes with changes in ocular dimensions.

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Conflict of interest statement

The University of Miami and authors MR, FM, and JMP stand to benefit from intellectual property in the OCT technology used in this study.

Figures

Fig. 1.
Fig. 1.
(left) Optical schematic of the OCT (yellow), autorefractor (red), and fixation target (blue) combined with three beamsplitters (DM1, BS1, and DM2). The fixation target uses two channels to enable both step and ramp accommodation stimuli. Components are labelled as follows: SLD, superluminescent diode; C, collimator; L1-L2, 4f-relay lenses of autorefractor; L3, objective lens for pupil camera; L1, Badal lens; L4, L6, auxiliary lenses; L5, L7, collimating lenses; DM1, DM2, dichroic mirror; BS1, BS2 pellicle beam splitters; BS3, cube beamsplitter, M1, M3, right angle mirror; M2, retroreflector. (right) Picture of the system.
Fig. 2.
Fig. 2.
Model eye calibration results. (left) correlation and (right) error of nominal versus measured sphere (D).
Fig. 3.
Fig. 3.
Human subject calibration results of mean spherical equivalent (MSE), J0 and J45. (Left) MSE, J0, and J45 measurements with custom aberrometer versus commercial autorefractor. (Right) Bland Altman plots to show agreement of MSE, J0, and J45 measurements between the two devices.
Fig. 4.
Fig. 4.
Accommodative response (ACC) (D), lens thickness (LT) (mm), anterior chamber depth (ACD) (mm), vitreous depth (VD) (mm), anterior lens curvature (ALR) (mm), and posterior lens curvature (PLR) (mm) versus time (s) of 21, 27, and 31 year old subjects to 2, 4, and 8 D ramp accommodation stimuli at 0.25 D/s. Vertical dotted lines indicate the start and end of the ramp stimuli as indicated in the legend. A representative run is shown for each subject.
Fig. 5.
Fig. 5.
Change in lens thickness (LT) (mm), anterior chamber depth (ACD) (mm), vitreous depth (VD) (mm), anterior lens radius (ALR) (mm), and posterior lens radius (PLR) (mm) versus accommodative response (D) of 21, 27, and 31 year old subjects to 8 D ramp accommodation stimuli at 0.25 D/s. A representative run is shown for each subject.
See this image and copyright information in PMC

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