Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Mar;37(2):425-30.

Anti-kinetochore antibodies: use as probes for inactive centromeres

D E Merry, S Pathak, T C Hsu, B R Brinkley

Anti-kinetochore antibodies: use as probes for inactive centromeres

D E Merry et al. Am J Hum Genet. 1985 Mar.

Abstract

Application of a modified immunofluorescence technique using an anti-kinetochore serum enables cytogeneticists to obtain quality metaphase spreads and to localize kinetochores. In a patient with a 45, XX, -9, -11, tdic (9p;11p) constitution, we found that the dicentric marker chromosome has an intensely fluorescent kinetochore (no. 11), the functional centromere, and a less intensely fluorescent kinetochore (no. 9), the inactive centromere. The data suggest that in the process of tandem fusion (telomere-telomere between 11p and 9p), the centromere of chromosome 9 was not deleted, but, rather, inactivated.

PubMed Disclaimer

References

    1. Lancet. 1971 Oct 30;2(7731):971-2 - PubMed
    1. Humangenetik. 1972;16(3):217-26 - PubMed
    1. Am J Hum Genet. 1974 Jan;26(1):83-92 - PubMed
    1. Nature. 1974 Mar 1;248(5443):55 - PubMed
    1. Exp Cell Res. 1975 Jan;90(1):87-94 - PubMed

Publication types

LinkOut - more resources