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. 2024 Jun;38(6):453-462.
doi: 10.13201/j.issn.2096-7993.2024.06.001.

[Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs （2024, Chengdu）]

[Article in Chinese]
Juan Meng, Jing Ye, LiJiang Zhang, YuanTeng Xu, WenLong Liu, YuCheng Yang, XiangDong Wang, Yan Jiang, QianHui Qiu, Jian Li, ShaoQing Yu, Feng Liu, HongFei Lou, HongTian Wang, GuoDong Yu, Rui Xu, CuiDa Meng, Na Sun, JianJun Chen, Ming Zeng, ZhiHai Xie, YueJi Sun, Juan Tang, KeQing Zhao, WeiTian Zhang, ZhaoHui Shi, ChengLi Xu, YanLi Yang, MeiPing Lu, HuiPing Ye, Xin Wei, Bin Sun, YunFang An, YaNan Sun, YuRong Gu, TianHong Zhang, Luo Ba, QinTai Yang, Yu Xu, Gui Yang, HaiYu Hong, KeJun Zuo, HuaBin Li

[Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs （2024, Chengdu）]

[Article in Chinese]
Juan Meng et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Jun.

Abstract
in English, Chinese

Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease （N-ERD） is a chronic respiratory disease characterized by eosinophilic inflammation, featuring chronic rhinosinusitis （CRS）, asthma, and intolerance to cyclooxygenase 1 （COX-1） inhibitors. The use of these medications can lead to an acute worsening of rhinitis and asthma symptoms. This condition has not yet received sufficient attention in China, with a high rate of misdiagnosis and a lack of related research. The Chinese Rhinology Research Group convened a group of leading young experts in otolaryngology from across the country, based on the latest domestic and international evidence-based medical practices to formulate this consensus.The consensus covers the epidemiology, pathogenesis, clinical manifestations, diagnostic methods, and treatment strategies for N-ERD, including pharmacotherapy, surgery, biologic treatments, and desensitization therapy. The goal is to improve recognition of N-ERD, reduce misdiagnosis, and enhance treatment outcomes.

摘要: 非甾体抗炎药加重呼吸道疾病（non-steroidal anti-inflammatory drugs-exacerbated respiratory disease，N-ERD）是一种慢性呼吸道嗜酸性炎症性疾病，其特征为慢性鼻窦炎（chronic rhinosinusitis ，CRS）、哮喘以及对环氧化酶-1（cyclooxygenase 1，COX-1）抑制剂不耐受, 使用此类药物后，患者出现鼻炎、哮喘症状急性加重的综合征。N-ERD在我国尚未引起足够重视，临床中漏诊比例较高，相关研究较缺乏。有鉴于此，中国鼻病研究协作组召集了国内鼻科学界的一线青年专家，结合国内外最新的循证医学依据，制订了本共识，共识包括疾病的流行病学、发病机制、临床表现、诊断方法以及治疗策略，包括药物治疗、手术、生物制剂治疗及脱敏治疗等方面。旨在提高对N-ERD的认识，减少漏诊，并提高治疗效果。.

Keywords: asthma; chronic rhinosinusitis; diagnosis; intolerance to non-steroidal anti-inflammatory drugs; non-steroidal anti-inflammatory drugs-exacerbated respiratory disease; treatment.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

Figures

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图 1
N-ERD诊断流程
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