Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jun;38(6):556-560.
doi: 10.13201/j.issn.2096-7993.2024.06.019.

[Progress of allergic rhinitis research based on transcriptome sequencing]

[Article in Chinese]
Haoxiang Zhang  1 , Yanjie Wang  1 , Fengli Cheng  1 , Yunfang An  1 , Changqing Zhao  1
Affiliations
Review

[Progress of allergic rhinitis research based on transcriptome sequencing]

[Article in Chinese]
Haoxiang Zhang et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Jun.

Abstract
in English, Chinese

Traditional studies on allergic rhinitis（AR） have mainly adopted animal models and biomolecular approaches. In addition, the advent of transcriptome sequencing technology is promoting the development of AR at the genetic level. Recently, many scholars have focused on the role of common RNA in the pathogenesis of AR, suggesting that breakthroughs have been made in the field of AR bioinformatics analysis. This review aims to summarize the research advances in AR, the development of transcriptome sequencing technology, and the application of transcriptome sequencing in AR, in order to explore potential drug targets for AR treatment and provide new insights into precision medicine.

摘要: 传统研究变应性鼻炎（allergic rhinitis，AR）主要通过动物模型和分子生物学方法研究，转录组测序技术的诞生推进了AR基因层面的探索。近年来重点聚焦于常见RNA在AR中作用的研究，提示AR的生物信息学分析已取得突破性进展。本文拟综述AR研究进展、转录组测序技术的发展、转录组测序在AR中的应用等，以期为临床挖掘AR潜在的药物靶点，为精准治疗提供参考。.

Keywords: allergic rhinitis; bioinformatics; transcriptome sequencing.

PubMed Disclaimer

Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

References

    1. 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组 中国变应性鼻炎诊断和治疗指南(2022年, 修订版) 中华耳鼻咽喉头颈外科杂志. 2022;57(2):8–31.
    1. Velculescu VE, Zhang L, Vogelstein B, et al. Serial analysis of gene expression. Science. 1995;270(5235):484–487. doi: 10.1126/science.270.5235.484. - DOI - PubMed
    1. Hutter C, Zenklusen JC. The Cancer Genome Atlas: Creating Lasting Value beyond Its Data. Cell. 2018;173(2):283–285. doi: 10.1016/j.cell.2018.03.042. - DOI - PubMed
    1. Barrett T, Wilhite SE, Ledoux P, et al. NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013;41(Database issue):D991–995. - PMC - PubMed
    1. Ghandi M, Huang FW, Jané-Valbuena J, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019;569(7757):503–508. doi: 10.1038/s41586-019-1186-3. - DOI - PMC - PubMed

LinkOut - more resources