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Review
. 2024 Jun 10.
doi: 10.1007/s12265-024-10530-w. Online ahead of print.

Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression

Li-Hua Yu  1   2 , Ge-Lin Zhang  3   4
Affiliations
Review

Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression

Li-Hua Yu et al. J Cardiovasc Transl Res. .

Abstract

Recent research shows exercise is good for heart health, emphasizing the importance of physical activity. Sedentary behavior increases the risk of cardiovascular disease, while exercise can help prevent and treat it. Additionally, physical exercise can modulate the expression of lncRNAs, influencing cardiovascular disease progression. Therefore, understanding this relationship could help identify prospective biomarkers and therapeutic targets pertaining to cardiovascular ailments. This review has underscored recent advancements concerning the potential biomarkers of lncRNAs in cardiovascular diseases, while also summarizing existing knowledge regarding dysregulated lncRNAs and their plausible molecular mechanisms. Additionally, we have contributed novel perspectives on the underlying mechanisms of lncRNAs, which hold promise as potential biomarkers and therapeutic targets for cardiovascular conditions. The knowledge imparted in this review may prove valuable in guiding the design of future investigations and furthering the understanding of lncRNAs as diagnostic, prognostic, and therapeutic biomarkers for cardiovascular diseases.

Keywords: Cardiovascular Diseases; LncRNAs; Physical Exercise; Sedentary Behavior; Therapeutic Targets.

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