The use of amniocentesis in preterm premature rupture of membranes

Abstract

Amniocentesis has recently been advocated as a useful diagnostic adjunct in the management of the patient with preterm premature rupture of membranes (PROM). Although studies are limited, transabdominal inspection of amniotic fluid for a mature phospholipid lung profile or evidence of incipient sepsis appears helpful in reducing the risk of prematurity and infection in the gravida and neonate. In addition, amniocentesis in this group of patients is technically feasible if ultrasound is used concomitantly. Limitations to this procedure include the inability to identify neonates at risk for nonpulmonary complications of prematurity such as intraventricular hemorrhage. Physicians should be aware of their individual laboratory and nursery limitations along with current infectious morbidity statistics before initiating this management protocol.