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. 2024 Jun 7;19(1):20240972.
doi: 10.1515/med-2024-0972. eCollection 2024.

Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study

Jianyuan Liao  1 , Lifang Zhang  2 , Gangxin Chen  3 , Yuxing Luo  4
Affiliations

Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study

Jianyuan Liao et al. Open Med (Wars). .

Abstract

Community-acquired pneumonia (CAP) is a common respiratory disease in children. This prospective cohort study of 110 children with CAP and 100 healthy children investigated the relationship between the levels of vitamin A, D and E and inflammatory markers, such as tumour necrosis factor (TNF-a), interleukin-1 (IL-1), interleukin-10 (IL-10), neutrophils (NE) and C-reactive protein (CRP), in CAP. The haemoglobin, leukocyte concentration, NE, monocytes and CRP concentration in the CAP group showed significant differences (P < 0.05). The levels of vitamin A, D and E in the CAP group were lower than those in the control group, while the levels of TNF-a and IL-1 were higher than in the control group; the differences were statistically significant (P < 0.05). The IL-10 levels showed no significant differences (P > 0.05). Pearson analysis revealed that the vitamin A, D and E levels were all correlated with the TNF-a, IL-10 and CRP levels (P < 0.05). The vitamin A, D and E levels of the CAP children were lower than those of the healthy children. Thus, the content of fat-soluble vitamins is correlated with the secretion of TNF-a and IL-10. The research provides a new direction for the prevention, diagnosis and treatment of CAP.

Keywords: IL-1; IL-10; TNF-a; fat-soluble vitamins; paediatric CAP.

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Conflict of interest statement

Conflict of interest: The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow chart: study design.
Figure 2
Figure 2
Correlation between fat-soluble vitamins and inflammatory factors in paediatric CAP patients.
See this image and copyright information in PMC

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