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Review
. 2024 May 16:60-61:101435.
doi: 10.1016/j.nmni.2024.101435. eCollection 2024 Aug-Oct.

The effect of polyclonal and monoclonal based antibodies as promising potential therapy for treatment of sepsis: A systematic review

Marzie Mahdizade Ari  1 , Mohammad Esmaeil Amini  1 , Mohammad Sholeh  2 , Abed Zahedi Bialvaei  3
Affiliations
Review

The effect of polyclonal and monoclonal based antibodies as promising potential therapy for treatment of sepsis: A systematic review

Marzie Mahdizade Ari et al. New Microbes New Infect. .

Abstract

While mortality caused by sepsis remains an unsolved problem, studies showed conflicting results about effectiveness of monoclonal and polyclonal antibodies in patients suffering sepsis. For this reason, this current study provides an update of review clinical randomized trial studies until March 2024. The main object of this study is to determine effects of monoclonal and polyclonal antibodies on mortality rate and hospitalization of patients suffering sepsis. Search of Scopus, Web of science, EMBASE, PubMed and Cochrane were performed and randomized controlled trials which conducted in patients with septic shock or bacterial sepsis were included. Two reviewers assessed all searched trials for eligibility according to already defined criteria and did data collection and analyses afterwards. Present study showed monoclonal and polyclonal antibodies are a safe strategy with mild-to-moderate adverse effects. However, most studies indicate no significant change among inter-and intra-group comparison (p > 0.05) and further studies are needed, results showed an increase in survival rate, ventilator-and ICU-free days, resolve organ dysfunction, mediating inflammation related cytokines.

Keywords: Monoclonal antibody; Randomized clinical trial; Sepsis; Septic shock; Septicemia.

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Conflict of interest statement

The authors declare that they have no known competing interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flow chart of study selection for inclusion in the systematic review. Most articles related to animals, observational studies, and systematic reviews/meta-analyses or unpublished were excluded. Finally, nineteen articles were excluded from the study due to the non-availability of the full text and also the lack of their English version.
Fig. 2
Fig. 2
Adverse effects induced by m-AB and p-Ab in patients with bacterial sepsis or septic shock.
See this image and copyright information in PMC

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