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Review
. 2024 Jun 10:12:tkae012.
doi: 10.1093/burnst/tkae012. eCollection 2024.

Hypoxic environment of wounds and photosynthesis-based oxygen therapy

Shuning Tian  1 , Shenyu Tan  1 , Mingjie Fan  1 , Wenlin Gong  1 , Tianchang Yang  1 , Fangwen Jiao  2 , Hongzhi Qiao  1
Affiliations
Review

Hypoxic environment of wounds and photosynthesis-based oxygen therapy

Shuning Tian et al. Burns Trauma. .

Abstract

The hypoxic environment is among the most important factors that complicates the healing of chronic wounds, such as venous leg ulcers, pressure injuries and diabetic foot ulcers, which seriously affects the quality of life of patients. Various oxygen supply treatments are used in clinical practice to improve the hypoxic environment at the wound site. However, problems still occur, such as insufficient oxygen supply, short oxygen infusion time and potential biosafety risks. In recent years, artificial photosynthetic systems have become a research hotspot in the fields of materials and energy. Photosynthesis is expected to improve the oxygen level at wound sites and promote wound healing because the method provides a continuous oxygen supply and has good biosafety. In this paper, oxygen treatment methods for wounds are reviewed, and the oxygen supply principle and construction of artificial photosynthesis systems are described. Finally, research progress on the photosynthetic oxygen production system to promote wound healing is summarized.

Keywords: Chronic wounds; Hypoxia; Hypoxia environment; Oxygen therapy; Photosynthesis; Wound healing.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Relationship between chronic wounds and a hypoxic environment. (1) Oxygenase catalyzes the production of oxidants by consuming large amounts of oxygen. (2) Collagen formation and fibroblast proliferation are oxygen dependent. (3) A disrupted vascular supply immediately obstructs oxygen delivery to the wound. (4) Angiogenesis during endothelial cell differentiation also consumes large amounts of oxygen. ROS reactive oxygen species
Figure 2
Figure 2
Principle of oxygen production through photosynthesis and composition of photosynthetic oxygen production systems
See this image and copyright information in PMC

References

    1. Haalboom M. Chronic wounds: innovations in diagnostics and therapeutics. Curr Med Chem. 2018;25:5772–81. - PubMed
    1. Olsson M, Järbrink K, Divakar U, Bajpai R, Upton Z, Schmidtchen A, et al. The humanistic and economic burden of chronic wounds: a systematic review. Wound Repair Regen. 2019;27:114–25. - PubMed
    1. Ouyang J, Ji X, Zhang X, Feng C, Tao W. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment. Proc Natl Acad Sci USA. 2020;117:28667–77. - PMC - PubMed
    1. Tang N, Zhang R, Zheng Y, Wang J, Khatib M, Jiang X, et al. Highly efficient self-healing multifunctional dressing with antibacterial activity for Sutureless wound closure and infected wound monitoring. Adv Mater. 2022;34:e2106842. 10.1002/adma.202106842. - DOI - PubMed
    1. Schreml S, Szeimies RM, Prantl L, Karrer S, Landthaler M, Babilas P. Oxygen in acute and chronic wound healing. Br J Dermatol. 2010;163:257–68. - PubMed