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. 2024 Jun;30(3):267-273.
doi: 10.1007/s13365-024-01214-x. Epub 2024 Jun 11.

Serum mir-142-3p release in children with viral encephalitis and its relationship with nerve injury and inflammatory response

Yanjiang Liu  1 , ZhenFang Wang  2 , Xiaoli Liu  2 , Qinghua Yang  2 , Zhuoling Tian  2 , Junmei Liu  2
Affiliations

Serum mir-142-3p release in children with viral encephalitis and its relationship with nerve injury and inflammatory response

Yanjiang Liu et al. J Neurovirol. 2024 Jun.

Abstract

Background: Viral encephalitis (VE) is a common infectious disease of the central nervous system in children. Children with severe disease may have progressive neurological damage and even lead to death.

Aims: To assess the serum miR-142-3p levels in children with VE and the correlation between miR-142-3p and the severity and prognosis of VE. Besides, its relationship with nerve injury and inflammatory response was assessed.

Methods: Children with VE were regarded as a case group and healthy children served as control. The content of serum miR-142-3p was determined using real-time quantitative PCR. The risk factors associated with severity and prognosis of cases were evaluated using logistic analysis. The discrepancy in miR-142-3p levels, nerve injury-related indicators, and inflammatory cytokines were contrasted among groups. The ROC curve was conducted to assess the diagnostic performance of serum miR-142-3p in predicting prognosis of children with VE.

Results: The altered expression of miR-142-3p in serum of children with VE was enhanced in contrast to healthy control. Serum nerve injury indicators MBP, β-EP, and NSE levels and serum inflammatory cytokines IL-6, IL-18, and IFN-γ were high in children with VE in contrast to healthy control, and had positive relevance with serum miR-142-3p. Besides, serum miR-142-3p was a risk factor associated with the severity and prognosis of children with VE. Serum miR-142-3p had diagnostic performance in predicting the prognosis of children with VE.

Conclusion: Serum miR-142-3p content is high in children with VE and maybe a diagnosis marker for predicting prognosis. The specific miR-142-3p expression may be directly related to the severity of nerve injury and inflammatory response for VE.

Keywords: Biomarker; Children; Nerve injury; Viral encephalitis; miR-142-3p.

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References

    1. Ai J, Xie Z, Liu G, Chen Z, Yang Y, Li Y et al (2017) Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study. BMC Infect Dis 17(1):494 - DOI - PubMed - PMC
    1. Boese AS, Saba R, Campbell K, Majer A, Medina S, Burton L et al (2016) MicroRNA abundance is altered in synaptoneurosomes during prion disease. Mol Cell Neurosci 71:13–24 - DOI - PubMed
    1. Britton PN, Khandaker G, Booy R, Jones CA (2014) The causes and consequences of Childhood Encephalitis in Asia. Infect Disord Drug Targ 14(2):78–88 - DOI
    1. Chen S, Deng Y, Chen H, Lin Y, Yang X, Sun B et al (2022) Neuronal miR-138 represses HSV-2 lytic infection by regulating viral and Host Genes with mechanistic differences from HSV-1. J Virol 96(9):e0034922 - DOI - PubMed
    1. Costa BKD, Sato DK (2020) Viral encephalitis: a practical review on diagnostic approach and treatment. Jornal De Pediatria 96(1):12–19 - DOI - PubMed

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