Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Aug;43(8):2689-2699.
doi: 10.1007/s10067-024-07026-y. Epub 2024 Jun 11.

Anasarca and spontaneous intramuscular haemmorhage in a dermatomyositis patient: case report and review of the literature

Ioannis Xynogalas  1 , Polychroniadis Michail  2 , Georgios Katsikas  2 , Dimitris Exarhos  3 , Kallimachos Papachristos  3 , Anastasios Karamanakos  2
Affiliations
Review

Anasarca and spontaneous intramuscular haemmorhage in a dermatomyositis patient: case report and review of the literature

Ioannis Xynogalas et al. Clin Rheumatol. 2024 Aug.

Abstract

Dermatomyositis is a rare, autoimmune systemic disorder of unknown aetiology that presents as a constellation of clinical symptoms and signs primarily affecting skin and muscles. Patients with dermatomyositis can present with rare "non-canonical" manifestations. Focal or generalised oedema is an infrequent and often overlooked symptom of the disease, while spontaneous intramuscular haemorrhage is an even rarer and under-recognised, life-threatening complication that constitutes a medical emergency for clinical physicians. There are no known predisposing factors able to predict which patients will develop this complication and specific instructions considering treatment approach are currently lacking. Herein, we present a case of a patient with dermatomyositis complicated by both anasarca and spontaneous intramuscular haemorrhage. In order to raise awareness and timely diagnosis of such patients, we provide a review of the relevant literature and of the cases reported this far.

Keywords: Anti-NXP-2 antibodies; Dermatomyositis; Haemorrhagic myositis; Idiopathic inflammatory myositis; Oedema.

PubMed Disclaimer

References

    1. Goussot R, Wettlé C, Le Coz C, Cribier B, Lipsker D (2016) Dermatomyosite œdémateuse sévère. Ann Dermatol Venereol 143(3):202–209. https://doi.org/10.1016/j.annder.2015.10.594 - DOI - PubMed
    1. Smyth AE (2000) Acute oedematous dermatomyositis. Ann Rheum Dis 59(7):574b–5574. https://doi.org/10.1136/ard.59.7.574b - DOI
    1. Gorelik O et al (2001) Acute inflammatory myopathy with severe subcutaneous edema, a new variant? Report of two cases and review of the literature. Rheumatol Int 20(4):163–166. https://doi.org/10.1007/s002960000093 - DOI - PubMed
    1. Mroué KH, Sharara NH, Rbeiz JG, Arayssi TK (2003) A case of edematous dermatomyositis. J Rheumatol 30(12):2722–3 - PubMed
    1. Khan N (2020) A rare case of NXP-2 positive dermatomyositis. Archive of Clinical Cases 7(4): 68–71. https://doi.org/10.22551/2020.29.0704.10176

LinkOut - more resources