Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Osteonecrosis Imaging

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Osteonecrosis Imaging

Oana M. Stroie et al.
Free Books & Documents

Excerpt

Osteonecrosis is ischemia of bone due to inadequate vascular supply. This condition results in bone tissue death and loss of structural integrity. If left untreated, it can lead to bone collapse. This condition is also known as avascular necrosis or aseptic necrosis when it involves the epiphysis and as bone infarct when it involves metadiaphyseal regions of bone.

Osteonecrosis is common and typically asymptomatic in its early stages. This condition affects various bones in the body, including hips, knees, shoulders, ankles, and small bones of hands and feet. Some of the most common causes of osteonecrosis include chronic corticosteroid use, alcohol use disorder, trauma, and idiopathic causes. Other common predispositions include systemic diseases such as sickle cell anemia and collagen vascular disease.

Osteonecrosis may be asymptomatic in its early stage. This condition can also present with limited movement, inability to bear weight, significant pain, and swelling of the affected joint. Recognizing various presentations of osteonecrosis is crucial. In addition, understanding when and what further necessitates evaluation is important.

When osteonecrosis involves the small bones of hands and feet or epiphysis of long bones, it is essential to assess the risk of secondary complications such as subchondral collapse. Imaging modalities used to evaluate osteonecrosis include plain radiographs, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine studies. However, knowing which modality is most sensitive at a certain point in the patient's clinical presentation and when it is necessary is crucial. Early diagnosis and treatment of osteonecrosis affecting epiphyseal locations remains the key to joint preservation.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Oana Stroie declares no relevant financial relationships with ineligible companies.

Disclosure: Van Vu declares no relevant financial relationships with ineligible companies.

References

    1. Murphey MD, Foreman KL, Klassen-Fischer MK, Fox MG, Chung EM, Kransdorf MJ. From the radiologic pathology archives imaging of osteonecrosis: radiologic-pathologic correlation. Radiographics. 2014 Jul-Aug;34(4):1003-28. - PubMed
    1. George G, Lane JM. Osteonecrosis of the Femoral Head. J Am Acad Orthop Surg Glob Res Rev. 2022 May 01;6(5) - PMC - PubMed
    1. Shah KN, Racine J, Jones LC, Aaron RK. Pathophysiology and risk factors for osteonecrosis. Curr Rev Musculoskelet Med. 2015 Sep;8(3):201-9. - PMC - PubMed
    1. Morag Y, Morag-Hezroni M, Jamadar DA, Ward BB, Jacobson JA, Zwetchkenbaum SR, Helman J. Bisphosphonate-related osteonecrosis of the jaw: a pictorial review. Radiographics. 2009 Nov;29(7):1971-84. - PubMed
    1. Tasu JP, Duboe PO, Florez N, Herpe G. Avascular osteonecrosis of the hip: The vision of the radiologist (radiology, MRI, CT and scintigraphy). Morphologie. 2021 Jun;105(349):85-93. - PubMed

Publication types

LinkOut - more resources