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. 1979 Dec 21;206(4425):1421-3.
doi: 10.1126/science.388619.

Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes

A A Like, A A Rossini, D L Guberski, M C Appel, R M Williams

Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes

A A Like et al. Science. .

Abstract

Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.

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