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Case Reports
. 2024 Jun 11;111(2):312-316.
doi: 10.4269/ajtmh.23-0684. Print 2024 Aug 7.

Case Report: Neurobrucellosis Presenting as Malignancy

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Case Reports

Case Report: Neurobrucellosis Presenting as Malignancy

Andrea S Salcedo et al. Am J Trop Med Hyg. .

Abstract

Neurobrucellosis, caused by Brucella species, is a zoonotic infection that may involve the central nervous system. Although uncommon, it can manifest as a solitary intracranial mass. We report a case of neurobrucellosis in a 25-year-old woman from Peru who presented with headache, weight loss, and right-side hemiparesis and paresthesia. A contrast-enhanced magnetic resonance imaging scan revealed an intracerebral mass in the left temporal lobe. Serum testing subsequently were positive. Brain biopsy demonstrated non-necrotizing granulomas without malignant cells. Neurobrucellosis should be considered in the differential diagnosis of brain space occupying lesions in endemic countries.

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Conflict of interest statement

Disclosure: The patient’s written consent was obtained. Local committee approval does not apply in this case.

Figures

Figure 1.
Figure 1.
(A) Axial T1-weighted contrast-enhanced magnetic resonance imaging reported cerebral mass in left temporal lobe with peripheral edema (red arrow). (B) Fluid attenuated inversion recovery sequence showing expansive lesion in temporal lobe (red arrow). Both sequences showed a shift of midline.
Figure 2.
Figure 2.
(A–C) Hematoxylin and eosin–stained microphotography of brain parenchyma revealed a dense lymphocytic inflammatory infiltrate with the formation of non-necrotizing granulomas and multinucleated giant cells. Congestion and edema of the neuropil were also noticed.
Figure 3.
Figure 3.
At 6-month follow-up, (A) axial T1-weighted contrast-enhanced magnetic resonance imaging and (B) fluid attenuated inversion recovery sequence showed a noticeable decrease in the lesion of the temporal lobe.

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References

    1. Patra S, Kalwaje Eshwara V, Pai AR, Varma M, Mukhopadhyay C, 2020. Evaluation of clinical, diagnostic features and therapeutic outcome of neurobrucellosis: A case series and review of literature. Int J Neurosci 132: 1080–1090. - PubMed
    1. Guven T, Ugurlu K, Ergonul O, Celikbas AK, Gok SE, Comoglu S, Baykam N, Dokuzoguz B, 2013. Neurobrucellosis: Clinical and diagnostic features. Clin Infect Dis 56: 1407–1412. - PubMed
    1. Fatani DF, Alsanoosi WA, Badawi MA, Thabit AK, 2019. Ceftriaxone use in brucellosis: A case series. IDCases 18: e00633. - PMC - PubMed
    1. MINSA , 2022. Situación de brucelosis humana en el Perú, una revisión de dat 2009–2018 del sistema HIS–MINSA. Available at: https://www.dge.gob.pe/epipublic/uploads/boletin/boletin_20218.pdf. Accessed 17 September, 2022.
    1. Negrón M, Tiller R, Kharod G, 2024. Brucellosis. CDC Yellow Book 2024: Health Information for International Travel [e-book] New York, NY: Oxford University Press; 1st ed. Available from: https://wwwnc.cdc.gov/travel/yellowbook/2024/infections-diseases/brucell.... Accessed May 11, 2024.

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