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Practice Guideline
. 2024 Jun;22(2 D):e240029.
doi: 10.6004/jnccn.2024.0029.

Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology

Al B Benson  1 , Alan P Venook  2 , Mohamed Adam  2 , George Chang  3 , Yi-Jen Chen  4 , Kristen K Ciombor  5 , Stacey A Cohen  6 , Harry S Cooper  7 , Dustin Deming  8 , Ignacio Garrido-Laguna  9 , Jean L Grem  10 , Paul Haste  11 , J Randolph Hecht  12 , Sarah Hoffe  13 , Steven Hunt  14 , Hisham Hussan  15 , Kimberly L Johung  16 , Nora Joseph  17 , Natalie Kirilcuk  18 , Smitha Krishnamurthi  19 , Midhun Malla  20 , Jennifer K Maratt  11 , Wells A Messersmith  21 , Jeffrey Meyerhardt  22 , Eric D Miller  23 , Mary F Mulcahy  1 , Steven Nurkin  24 , Michael J Overman  3 , Aparna Parikh  25 , Hitendra Patel  26 , Katrina Pedersen  14 , Leonard Saltz  27 , Charles Schneider  28 , David Shibata  29 , Benjamin Shogan  30 , John M Skibber  3 , Constantinos T Sofocleous  27 , Anna Tavakkoli  31 , Christopher G Willett  32 , Christina Wu  33 , Lisa A Gurski  34 , Jenna Snedeker  34 , Frankie Jones  34
Affiliations
Practice Guideline

Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology

Al B Benson et al. J Natl Compr Canc Netw. 2024 Jun.

Abstract

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States. Management of disseminated metastatic CRC involves various active drugs, either in combination or as single agents. The choice of therapy is based on consideration of the goals of therapy, the type and timing of prior therapy, the mutational profile of the tumor, and the differing toxicity profiles of the constituent drugs. This manuscript summarizes the data supporting the systemic therapy options recommended for metastatic CRC in the NCCN Guidelines for Colon Cancer.

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